Evidence map›Paper›PMID 39056064›Full record

ArticleChemical & biomedical imaging2024

Non-Small Cell Lung Cancer Imaging Using a Phospholipase A2 Activatable Fluorophore.

Michael C Hart, Ritesh K Isuri, Drew Ramos, Sofya A Osharovich, Andrea E Rodriguez, Stefan Harmsen, Grace C Dudek, Jennifer L Huck, David E Holt, Anatoliy V Popov and 2 more

Abstract read
In one paragraph

Article in Chemical & biomedical imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael C HartDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ritesh K IsuriDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID https://orcid.org/0009-0004-1710-6562
Drew RamosDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Sofya A OsharovichDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Andrea E RodriguezDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Stefan HarmsenDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Grace C DudekDepartment of Biology, University of Pennsylvania, 102 Leidy Laboratories 433 S University Ave, Philadelphia, Pennsylvania 19104, United States.
Jennifer L HuckDepartment of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
David E HoltDepartment of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Anatoliy V PopovDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID https://orcid.org/0000-0002-4678-6307
Sunil SinghalDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Edward J DelikatnyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
Shared Resource - Core A: Administrative CoreP01CA254859 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Madduri S Srinivasarao · 2022 to 2026
$10.0M
Translating phospholipase activatable fluorophores for the sensitive detection of non-small cell lung cancerR01CA266234 · NCI · UNIVERSITY OF PENNSYLVANIA · PI EDWARD J DELIKATNY, Sunil Singhal · 2022 to 2026
$2.4M
Near-infrared Choline Kinase Sensors for Intraoperative Identification of Lung Tumor MarginsR01CA226412 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DELIKATNY, EDWARD J, SINGHAL, SUNIL · 2018 to 2022
$1.8M
Phospholipase-activated theranostics for PDT of breast cancerR01CA201328 · NCI · UNIVERSITY OF PENNSYLVANIA · PI POPOV, ANATOLIY VELTEROVICH · 2016 to 2019
$1.5M
NCI NIH HHS P01 CA254859NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA201328NCI NIH HHS R01 CA226412NCI NIH HHS R01 CA266234NCRR NIH HHS UL1 RR024134NIGMS NIH HHS T32 GM008076
6 · The paper itself

Abstract

Lung cancer, the most common cause of cancer-related death in the United States, requires advanced intraoperative detection methods to improve evaluation of surgical margins. In this study we employed DDAO-arachidonate (DDAO-A), a phospholipase A2 (PLA2) activatable fluorophore, designed for the specific optical identification of lung cancers in real-time during surgery. The

Identifiers

PMID39056064
PMCPMC11267604

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.