ArticleiScience2024
MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways.Nature communications · 2026Article
- A naturally synonymous mutation modulates an ERK-centered regulatory network to mediate thermotolerance divergence in Crassostrea oysters.Communications biology · 2026Article
- scCCVGBen for benchmarking of single-cell representation learning anchored on a centroid-coupled variational graph attention autoencoder across scRNA-seq and scATAC-seq.Frontiers in genetics · 2026Article
- Membrane Lipid Remodeling Strategies Regulate Fluidity for Acute Temperature Adaptation in Oysters.Evolutionary applications · 2025Article
- The Molecular Mechanism ofInternational journal of molecular sciences · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
Pyruvate kinase (PK), as a key rate-limiting enzyme in glycolysis, has been widely used to assess the stress tolerance and sensitivity of organisms. However, its phosphorylation regulatory mechanisms mainly focused on human cancer research, with no reports in marine organisms. In this study, we firstly reported a conserved PK Ser11 phosphorylation site in mollusks, which enhanced enzyme activity by promoting substrate binding, thereby regulating divergent thermal metabolism of two allopatric congeneric oyster species with differential habitat temperature. It was phosphorylated by ERK kinase, and regulated by the classical MAPK pathway. The MAPK/ERK-PK signaling cascade responded to increased environmental temperature and exhibited stronger activation pattern in the relatively thermotolerant species (
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