Evidence map›Paper›PMID 39055938›Full record

ArticleiScience2024

Risk prediction of heart diseases in patients with breast cancer: A deep learning approach with longitudinal electronic health records data.

Sicheng Zhou, Anne Blaes, Chetan Shenoy, Ju Sun, Rui Zhang

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sicheng ZhouInstitute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
Anne BlaesDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
Chetan ShenoyCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Ju SunDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA.
Rui ZhangDivision of Computational Health Sciences, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.

Funding

Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRDR01AG078154 · NIA · UNIVERSITY OF MINNESOTA · PI HUA XU, RUI ZHANG · 2022 to 2026
$4.2M
A Translational Informatics Framework to Mine Efficacy and Safety of Dietary SupplementsR01AT009457 · NCCIH · UNIVERSITY OF MINNESOTA · PI RUI ZHANG · 2017 to 2026
$4.1M
SCH: A New Computational Framework for Learning from Imbalanced Biomedical DataR01CA287413 · NCI · UNIVERSITY OF MINNESOTA · PI CUI, YING, SUN, JU · 2023 to 2025
$1.2M
NCCIH NIH HHS R01 AT009457NCI NIH HHS R01 CA287413NIA NIH HHS R01 AG078154
6 · The paper itself

Abstract

Accurately predicting heart disease risks in patients with breast cancer is crucial for clinical decision support and patient safety. This study developed and evaluated predictive models for six heart diseases using real-world electronic health records (EHRs) data. We incorporated a trainable decay mechanism to handle missing values in the long short-term memory (LSTM) model, creating LSTM-D models to predict heart disease risk based on longitudinal EHRs data. Additionally, we deployed NLP methods to extract breast cancer phenotypes from clinical texts, integrating unstructured and structured data to enhance predictions. Our LSTM-D models outperformed baseline models in predicting congestive heart failure, coronary artery disease, cardiomyopathy, myocardial infarction, transient ischemic attack, and aortic regurgitation, with AUC scores ranging from 0.7189 to 0.9548. Observation windows of 12-24 months were found optimal for model performance. This research advances precise, personalized care strategies, enabling early intervention and improved management of cardiovascular risks in breast cancer survivors.

Indexed as

BioinformaticsCancer

Identifiers

PMID39055938
PMCPMC11269285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.