Evidence map›Paper›PMID 39055915›Full record

ArticleiScience2024

Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells.

Vivian Y Chang, Yuwei He, Samantha Grohe, Morgan R Brady, Aldi Chan, Rucha S Kadam, Tiancheng Fang, Amara Pang, Katherine Pohl, Evelyn Tran and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Vivian Y ChangDivision of Hematology-Oncology, Department of Pediatrics, UCLA, Los Angeles, CA, USA.
Yuwei HeDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Samantha GroheDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Morgan R BradyDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Aldi ChanDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Rucha S KadamDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Tiancheng FangDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.
Amara PangDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Katherine PohlDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Evelyn TranDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Michelle LiDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jenny KanDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yurun ZhangMolecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Josie J LuApplied Genomics, Computation and Translational Core, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Joshua P SasineDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Heather A HimburgDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Peibin YueDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.
John P ChuteDivision of Hematology & Cellular Therapy, Cedars Sinai Medical Center, Los Angeles, CA, USA.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Semaphorin signaling regulates vascular and hematopoietic regenerationR01HL086998 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P · 2008 to 2022
$4.6M
Mitigation of Radiation Injury via Vascular Regeneration and RemodelingU01AI156922 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P · 2020 to 2024
$2.6M
Regulation of Stem Cell Aging and Cancer by the Vascular NicheK08HL138305 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHANG, VIVIAN Y-J · 2017 to 2021
$891k
NCI NIH HHS P30 CA016042NHLBI NIH HHS K08 HL138305NHLBI NIH HHS R01 HL086998NIAID NIH HHS U01 AI156922
6 · The paper itself

Abstract

Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-renewal capacity and myeloid skewing. We report that culture of bone marrow (BM) HSCs from aged mice with epidermal growth factor (EGF) suppressed myeloid skewing, increased multipotent colony formation, and increased HSC repopulation in primary and secondary transplantation assays. Mice transplanted with aged, EGF-treated HSCs displayed increased donor cell engraftment within BM HSCs and systemic administration of EGF to aged mice increased HSC self-renewal capacity in primary and secondary transplantation assays. Expression of a dominant negative EGFR in Scl/Tal1

Indexed as

cellular physiologyfunctional aspects of cell biologyHuman physiologymolecular medicinestem cells research

Identifiers

PMID39055915
PMCPMC11269946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.