Evidence map›Paper›PMID 39055869›Full record

ArticleIranian journal of basic medical sciences2024

Synthesized diterpene lactone derivative attenuated Freund's complete adjuvant-induced arthritis in Wistar rats.

Patrick Francis Kimariyo, Sony Priya Kurati, Perupogu Suvarna Babu, Alfredi Alfred Moyo, Murali Krishna Kumar Muthyala

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Article in Iranian journal of basic medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patrick Francis KimariyoAU College of Pharmaceutical Sciences, Pharmaceutical Chemistry Department, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India.
Sony Priya KuratiAU College of Pharmaceutical Sciences, Pharmaceutical Chemistry Department, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India.
Perupogu Suvarna BabuAU College of Pharmaceutical Sciences, Pharmaceutical Chemistry Department, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India.
Alfredi Alfred MoyoMedicinal Chemistry Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, Maharashtra, India.
Murali Krishna Kumar MuthyalaAU College of Pharmaceutical Sciences, Pharmaceutical Chemistry Department, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: In this study, the SP-38 (Diterpene Lactone derivative) was designed, synthesized from clerodane diterpene (lactone) isolated from Materials and Methods: This study examined the Results: Administered SP-38 reduced arthritis index, paw volume, and joint swelling compared to the arthritic control group. Accordingly, rats treated with SP-38 showed a remarkable increase in body weight and improved biochemical, hematological, histopathological, and radiological parameters. Furthermore, it reduced the increased production of CRP and RF while simultaneously decreasing ESR in all SP-38-treated rats. However, SP-38 showed promising liver protection by reducing elevated serum levels of liver and kidney function markers SGOT, SGPT, and ALP. Furthermore, splenic index, TNF-α, and IL-6 levels were significantly reduced compared to arthritic control rats at certain doses. Conclusion: The result of the present study concludes that SP-38 has significant anti-arthritic potential in FCA-induced arthritis in Wistar rats. SP-38 therefore showed promising anti-arthritic activity, as evidenced by attenuation of inflammation, inflammatory markers, and pro-inflammatory cytokine levels.

Indexed as

Anti-arthriticAnti-rheumatoidClerodane diterpeneFCA modelRheumatoid arthritis

Identifiers

PMID39055869
PMCPMC11266735

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.