Evidence map›Paper›PMID 39055824›Full record

ArticleHeliyon2024

Investigation of the role of Cremophor RH 40 and Cremophor EL in the inhibition of efflux pump of

Muhammad Asim, Yasin Ahmad, Momin Khan, Zeeshan Ahmad, Awais Khalid, Pervaiz Ahmad, Abdulhameed Khan, Fakhrul Ahsan, Mohsin Kazi, Samer H Zyoud

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad AsimInstitute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Yasin AhmadSarhad Institute of Allied Health Sciences, Sarhad University of Science and Information Technology, Peshawar, Pakistan.
Momin KhanInstitute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar, Pakistan.
Zeeshan AhmadDepartment of Microbiology, Hazara University Mansehra, Khyber Pakhtunkhwa, 21300, Pakistan.
Awais KhalidDepartment of Physics, Hazara University Mansehra, Khyber Pakhtunkhwa, 21300, Pakistan.
Pervaiz AhmadDepartment of Physics, University of Azad Jammu and Kashmir, Muzaffarabad, 13100, Pakistan.
Abdulhameed KhanDepartment of Biotechnology, University of AJK, Muzaffarabad, Pakistan.
Fakhrul AhsanDepartment of Pharmaceutical and Biomedical Sciences, California Northstate University College of Pharmacy, Elk Grove, CA, 95757, USA.
Mohsin KaziDepartment of Pharmaceutics, College of Pharmacy, POBOX- 2457, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia.
Samer H ZyoudDepartment of Mathematics and Sciences, Ajman University, P.O. Box 346, Ajman, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is increasing emphasis on restoring the efficacy of existing antibiotics instead of developing new ones. Objectives: This study aimed to determine the role of Cremophor EL and Cremophor RH40 in the inhibition of efflux pumps in MDR Methods: Efflux pump-active MDR strains of Results: Out of 30 samples, 6 strains displayed high efflux pump activity. Both Cremophor EL and Cremophor RH40 showed efflux pump inhibitory roles. A 4-fold reduction in the MIC values of ciprofloxacin was observed when Cremophor EL was used along with ciprofloxacin, while a 6-fold reduction was observed when Cremophor RH40 was used along with ciprofloxacin. Both compounds showed synergistic effects with ciprofloxacin, ticarcillin and meropenem when used in a 24-well plate efflux pump inhibitory assay. Conclusion: The inhibition of the efflux pump of MDR

Indexed as

Cremophor ELCremophor RH40Efflux pump inhibitorsEthidium bromideMultidrug resistancePseudomonas aeruginosa

Identifiers

PMID39055824
PMCPMC11269872

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.