Evidence map›Paper›PMID 39055497›Full record

ArticleFrontiers in pharmacology2024

Bioassay-guided isolation of leishmanicidal cucurbitacins from

Maria Carolina Silva Marques, Nídia Cristiane Yoshida, Eduardo Caio Torres-Santos, Fernanda Rodrigues Garcez, Walmir Silva Garcez

Abstract read
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In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Carolina Silva Marques *Laboratory of Microbiology, Institute of Biosciences, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil.
Nídia Cristiane Yoshida *Laboratory of Bioactive Natural Products Research (PRONABio), Institute of Chemistry, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil.
Eduardo Caio Torres-SantosLaboratory of Trypanosomatid Biochemistry, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Fernanda Rodrigues Garcez *Laboratory of Bioactive Natural Products Research (PRONABio), Institute of Chemistry, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil.
Walmir Silva Garcez *Laboratory of Bioactive Natural Products Research (PRONABio), Institute of Chemistry, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Leishmaniasis, a neglected tropical parasitic disease, is regarded as a major public health problem worldwide. The first-line drugs for leishmaniasis suffer from limitations related to toxicity and the development of resistance in certain parasitic strains. Therefore, the discovery of alternative treatments for leishmaniasis is imperative, and natural products represent a valuable source of potential therapeutic agents. Methods: The present study aimed at finding new potential antileishmanial agents from the aerial parts of the medicinal plant Results: Antileishmanial assay-guided fractionation of the Conclusion: Our findings demonstrate that the fractions and cucurbitacin-type triterpenoids obtained from the aerial parts of

Indexed as

CucurbitaceaecucurbitacinLeishmania amazonensisleishmanicidal activityMomordica charantianeglected tropical disease

Identifiers

PMID39055497
PMCPMC11269121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.