Evidence map›Paper›PMID 39055270›Full record

ReviewJACC. Advances2024

Emerging Pathway to a Precision Medicine Approach for Angina With Nonobstructive Coronary Arteries in Women.

Nisha Hosadurg, Kelsey Watts, Shuo Wang, Kelly E Wingerter, Angela M Taylor, Todd C Villines, Amit R Patel, Jamieson M Bourque, Jonathan R Lindner, Christopher M Kramer and 2 more

Registry-linked trialAbstract readReview
In one paragraph

Review in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06948201 (Inorganic Nitrate as a Treatment for ANOCA), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06948201 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Inorganic Nitrate as a Treatment for ANOCA: NO-ANOCA

TypeinterventionalSponsorUniversity of VirginiaRan2025 to 2026Enrolled8ConditionsCoronary Microvascular Dysfunction (CMD), Angina Patients With Non-obstructive Coronary Artery DiseaseArms70mL Nitrate Rich Beetroot Juice followed by placebo (Nitrate depleted beetroot juice), Placebo (70 mL Nitrate depleted beetroot juice) followed by 70mL Nitrate Rich Beetroot Juice
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nisha HosadurgCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Kelsey WattsCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Shuo WangCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Kelly E WingerterCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Angela M TaylorCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Todd C VillinesCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Amit R PatelCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Jamieson M BourqueCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Jonathan R LindnerCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Christopher M KramerCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
Garima SharmaINOVA Heart and Vascular Institute, Fairfax, Virginia, USA.
Patricia F Rodriguez LozanoCardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Targeted CEU Imaging of Atherosclerosis and AngiogenesisR01HL078610 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LINDNER, JONATHAN R · 2004 to 2022
$6.8M
Augmentation of Tissue Perfusion with Ultrasound-mediated CavitationR01HL130046 · NHLBI · UNIVERSITY OF VIRGINIA · PI LINDNER, JONATHAN R · 2016 to 2023
$5.5M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
Advanced Non-invasive Imaging in the Investigation of Aortic Stenosis PathobiologyR01HL165422 · NHLBI · UNIVERSITY OF VIRGINIA · PI Jonathan R Lindner · 2022 to 2026
$3.5M
Innovative Therapy to Treat Women with Angina with Nonobstructive CAD (ANOCA) and Coronary Microvascular DiseaseK01HL174889 · NHLBI · UNIVERSITY OF VIRGINIA · PI Patricia Fiorella Rodriguez Lozano · 2024 to 2026
$486k
NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NHLBI NIH HHS K01 HL174889NHLBI NIH HHS R01 HL078610NHLBI NIH HHS R01 HL130046NHLBI NIH HHS R01 HL165422
6 · The paper itself

Abstract

Women are disproportionately affected by symptoms of angina with nonobstructive coronary arteries (ANOCA) which is associated with significant mortality and economic impact. Although distinct endotypes of ANOCA have been defined, it is underdiagnosed and is often incompletely characterized when identified. Patients are often unresponsive to traditional therapeutic options, which are typically antianginal, and the current ability to guide treatment modification by specific pathways is limited. Studies have associated specific genetic loci, transcriptomic features, and biomarkers with ANOCA. Such panomic data, in combination with known imaging and invasive diagnostic techniques, should be utilized to define more precise pathophysiologic subtypes of ANOCA in women, which will in turn help to identify targeted, effective therapies. A precision medicine-based approach to managing ANOCA incorporating these techniques in women has the potential to significantly improve their clinical care.

Indexed as

coronary microvascular dysfunctionendothelial dysfunctionepigeneticspatient-centered caresocial determinants of healthvasospasm

Identifiers

PMID39055270
PMCPMC11269914

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.