Evidence map›Paper›PMID 39055158›Full record

ArticleJACS Au2024

Addressing Reproducibility Challenges in High-Throughput Photochemistry.

Brenda Pijper, Lucía M Saavedra, Matteo Lanzi, Maialen Alonso, Alberto Fontana, Marta Serrano, José Enrique Gómez, Arjan W Kleij, Jesús Alcázar, Santiago Cañellas

Abstract read
In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025
    Review
  7. Precision Photochemistry: Every Photon Counts.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brenda PijperChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.ORCID https://orcid.org/0000-0002-1302-7865
Lucía M SaavedraChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.
Matteo LanziInstitute of Chemical Research of Catalonia (ICIQ), the Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain.
Maialen AlonsoChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.ORCID https://orcid.org/0000-0002-5279-2578
Alberto FontanaChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.
Marta SerranoChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.
José Enrique GómezChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.
Arjan W KleijInstitute of Chemical Research of Catalonia (ICIQ), the Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain.ORCID https://orcid.org/0000-0002-7402-4764
Jesús AlcázarChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.
Santiago CañellasChemical Capabilities, Analytical & Purification, Global Discovery Chemistry. Janssen-Cilag, S.A., E-45007 Toledo, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light-mediated reactions have emerged as an indispensable tool in organic synthesis and drug discovery, enabling novel transformations and providing access to previously unexplored chemical space. Despite their widespread application in both academic and industrial research, the utilization of light as an energy source still encounters challenges regarding reproducibility and data robustness. Herein we present a comprehensive head-to-head comparison of commercially available batch photoreactors, alongside the introduction of the use of batch and flow photoreactors in parallel synthesis. Hence, we aim to establish a reliable and consistent platform for light-mediated reactions in high-throughput mode. Herein, we showcase the identification of several platforms aligning with the rigorous demands for efficient and robust high-throughput experimentation screenings and library synthesis.

Identifiers

PMID39055158
PMCPMC11267557

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.