SynthesisClinical cardiology2024
Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta-Analysis.
Synthesis in Clinical cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Routine versus deferred percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: a frequentist and Bayesian meta-analysis of randomized trials with trial sequential analysis.International journal of cardiology. Heart & vasculature · 2026Review
- How to Individualize Coronary Assessment and Revascularization in Severe AS Patients Undergoing TAVI in the Era of Lifetime Management?Journal of clinical medicine · 2026Review
- Central retinal artery occlusion following transcatheter aortic valve implantation (TAVI) for aortic stenosis: a case report.BMC ophthalmology · 2026Article
- Article
- Global trends and research hotspots in transcatheter valve replacement for aortic regurgitation: a bibliometric and visualized analysis.Journal of cardiothoracic surgery · 2025Article
- Cabrol Procedure in Complex Aortic Root Reconstruction: A Case Series of Three Young Patients With Acute Aortic Syndrome.Clinical case reports · 2025Article
- Coronary Revascularization in the Era of TAVR: Timing, Strategy, and Outcomes.Clinical Medicine Insights. Cardiology · 2025Review
- Operation in the gray zone: is SAVR still useful in patients aged between 75 and 80 years?Future cardiologyArticle
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Authors and funding
14 authors.
Funding
Abstract
backgroundTranscatheter aortic valve implantation (TAVI) has been increasingly used in patients with severe aortic stenosis (AS). Since coronary artery disease (CAD) is common among these patients, it is crucial to choose the best method and timing of revascularization. This study aims to compare different timing strategies of percutaneous coronary intervention (PCI) in patients with severe AS undergoing TAVI to clarify whether PCI timing affects the patients' outcomes or not.
methodsA frequentist network meta-analysis was conducted comparing three different revascularization strategies in patients with CAD undergoing TAVI. The 30-day all-cause mortality, in-hospital mortality, all-cause mortality at 1 year, 30-day rates of myocardial infarction (MI), stroke, and major bleeding, and the need for pacemaker implantation at 6 months were analyzed in this study.
resultsOur meta-analysis revealed that PCI during TAVI had higher 30-day mortality (RR = 2.46, 95% CI = 1.40-4.32) and in-hospital mortality (RR = 1.70, 95% CI = [1.08-2.69]) compared to no PCI. Post-TAVI PCI was associated with higher 1-year mortality compared to other strategies. While no significant differences in major bleeding or stroke were observed, PCI during TAVI versus no PCI (RR = 3.63, 95% CI = 1.27-10.43) showed a higher rate of 30-day MI.
conclusionOur findings suggest that among patients with severe AS and CAD undergoing TAVI, PCI concomitantly with TAVI seems to be associated with worse 30-day outcomes compared with no PCI. PCI after TAVI demonstrated an increased risk of 1-year mortality compared to alternative strategies. Choosing a timing strategy should be individualized based on patient characteristics and procedural considerations.
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