ArticleDiabetology & metabolic syndrome2024
Association between the triglyceride-glucose (TyG) index and stroke risk in Chinese normal-weight adults: a population-based study.
Article in Diabetology & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Neutrophil-to-high-density lipoprotein cholesterol ratio and prevalent cardiometabolic multimorbidity in older adults: an exploratory cross-sectional analysis.BMC endocrine disorders · 2026Article
- Impact of Physical Activity on Stroke Risk in Middle-Aged and Older Adults.Brain and behavior · 2026Article
- Associations between the CHG index, its modified versions and incident stroke in patients with early-stage CKM syndrome: a nationwide cohort study.European journal of medical research · 2026Article
- Association of triglyceride-glucose index with risk of stroke and all-cause mortality in individuals with diabetes.Future cardiology · 2025Article
- The Association Between the Triglyceride-Glucose Index and the Risk of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Life (Basel, Switzerland) · 2025Article
- Assessment of six insulin resistance surrogate indexes for predicting stroke incidence in Chinese middle-aged and elderly populations with abnormal glucose metabolism: a nationwide prospective cohort study.Cardiovascular diabetology · 2025Article
- Article
- Association between triglyceride glucose-body mass index and outcomes in patients with acute ischemic stroke: a retrospective secondary analysis of a prospective Korean cohort.Frontiers in neurologyArticle
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Abstract
backgroundIdentifying high-risk populations and promoting stroke prevention measures can be achieved through studies on stroke and its risk factors. As a new alternative indicator of insulin resistance (IR), the triglyceride glucose (TyG) index may potentially increase stroke risk. However, the evidence confirming this association is inadequate and inconsistent, possibly due to variations in stroke assessment criteria or characteristics of the study populations. This study aims to evaluate the association between the TyG index and stroke risk level among individuals with normal-weight.
methodsA total of 30,895 participants aged ≥ 40 years with normal-weight were enrolled in this study. The TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Normal-weight was described as a body mass index (BMI) of 18.5-<24.0 kg/m
resultsResults showed that when the TyG index was considered as a continuous variable, each one unit increase in the TyG index was associated with a significantly higher risk of stroke [Moderate-risk (OR, 2.15; 95% CI, 2.03-2.28; P<0.001); High-risk (OR, 3.83; 95% CI, 3.57-4.10; P<0.001)]. Compared with Q1 of the TyG index, Q4 was significantly associated with moderate stroke risk (OR, 2.73; 95% CI, 2.50-2.99; P<0.001) and high stroke risk (OR, 5.39; 95% CI, 4.83-6.01; P<0.001). The continuous TyG index was an important risk factor for high stroke risk in the metabolically obese, normal-weight (MONW) individuals (OR, 3.44;95% CI, 2.92-4.06; P < 0.001). In the MONW individuals, when Q1 was used as a reference, participants in Q4 (OR, 5.33; 95% CI, 4.19-6.78; P < 0.001) was significantly associated with high stroke risk. Subgroup analysis showed significant interaction in the age and sex subgroups in the overall population (P
conclusionThe risk of stroke is increased with the TyG index among Chinese adults of normal weight; hence, the index may be an important indicator for identifying high-risk stroke populations among individuals with normal body weight.
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