ArticleNature communications2024
Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity.Epilepsia open · 2026Review
- Review
- Polygenic risk scores in neurological disorders: restless legs syndrome as a translational model.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
- Transfer learning enhances clinical utility of polygenic scores with small, phenotypically refined cohorts.Genome research · 2026Article
- Multi-Omics Dissection of the Shared Genetic Architecture Between Sleep Traits and Epilepsy.Biology · 2026Article
- Incorporation bias in clinical prediction models for epilepsy.Epilepsia open · 2026Article
- Development and validation of a deep survival model to predict time to seizure from routine electroencephalography.Epilepsia · 2026Article
- Structural brain imaging biomarkers for predicting seizure recurrence after a first unprovoked seizure.Epilepsia open · 2026Article
- Associations between epilepsy-related polygenic risk and brain morphology in childhood.Brain : a journal of neurology · 2026Article
- Epilepsy concordance in monozygotic twins: the role of common genetic variants.Brain : a journal of neurology · 2026Article
- Integrating rare and common variation in epilepsy genetics: from genetic architecture to penetrance and clinical expressivity.Frontiers in genetics · 2026Review
- Paternal valproate use and impact of shared genetic susceptibility on child neurodevelopment.Scientific reports · 2025Article
- Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies.Epilepsia · 2025Article
- NORSE, FIRES, and a Polygenic Trickle of Autoimmunity.Annals of neurology · 2025Article
- Improving diagnostic accuracy of routine EEG for epilepsy using deep learning.Brain communications · 2025Article
- Deep Learning for Epileptic Seizure Detection Using a Causal-Spatio-Temporal Model Based on Transfer Entropy.Entropy (Basel, Switzerland) · 2024Article
- Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.Nature communications · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
A diagnosis of epilepsy has significant consequences for an individual but is often challenging in clinical practice. Novel biomarkers are thus greatly needed. Here, we investigated how common genetic factors (epilepsy polygenic risk scores, [PRSs]) influence epilepsy risk in detailed longitudinal electronic health records (EHRs) of > 700k Finns and Estonians. We found that a high genetic generalized epilepsy PRS (PRS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.