Evidence map›Paper›PMID 39054295›Full record

ArticleAJNR. American journal of neuroradiology2024

An Optimized CT Protocol for Detecting Suspected Cauda Equina Syndrome: A Comparative Analysis with MRI.

Philip J Dempsey, David T Ryan, Gerard Lambe, Jack W Power, Andrew H Yates, Grace Kenny, Peter J MacMahon

Abstract readComparative Study
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Philip J DempseyFrom the Department of Radiology (P.J.D., D.T.R., G.L., J.W.P., A.H.Y., P.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland philipjdempsey@gmail.com.ORCID 0000-0001-5848-9003
David T RyanFrom the Department of Radiology (P.J.D., D.T.R., G.L., J.W.P., A.H.Y., P.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
Gerard LambeFrom the Department of Radiology (P.J.D., D.T.R., G.L., J.W.P., A.H.Y., P.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
Jack W PowerFrom the Department of Radiology (P.J.D., D.T.R., G.L., J.W.P., A.H.Y., P.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
Andrew H YatesFrom the Department of Radiology (P.J.D., D.T.R., G.L., J.W.P., A.H.Y., P.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
Grace KennyCentre for Experimental Pathogen Host Research (G.K.), University College Dublin, Dublin, Ireland.
Peter J MacMahonFrom the Department of Radiology (P.J.D., D.T.R., G.L., J.W.P., A.H.Y., P.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.ORCID 0000-0003-2235-6692

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeLumbar disc herniation, potentially leading to nerve root compression and cauda equina syndrome, is typically evaluated using MR imaging. However, the limited availability of MR imaging outside regular hours in certain health care systems poses considerable challenges. This purpose of this study was to prospectively evaluate the diagnostic accuracy of an optimized CT lumbar spine protocol as a potential alternative to MR imaging in assessing suspected neural compression. MATERIALS AND

methodsPatients presenting to the emergency department with suspected cauda equina syndrome or acute radicular symptoms secondary to lumbar disc herniation referred for MR imaging were prospectively enrolled for an additional CT optimized to assess spinal stenosis. An expert radiologist, blinded to clinical data, graded canal stenosis at each lumbar level on CT. The same grading process was applied to MR imaging after a 4-week interval to maintain blinding.

resultsFifty-nine individuals were included in the final analysis. In 22 (39%) cases, no significant stenosis was identified. In a further 22 (37%) cases, disc pathology was identified that was managed conservatively. Thirteen (22%) individuals proceeded to urgent surgical decompression. In 1 (2%) instance, an alternative diagnosis was identified. Compared with MR imaging, the sensitivity, specificity, and positive and negative predictive values for CT in detecting disc pathology in patients presenting with symptoms suggestive of acute neural compression were 97% (95% CI, 82%-99%), 97% (95% CI, 83%-99%), 97% (95% CI, 92%-99%), and 97% (95% CI, 83%-99%), respectively. CT accurately identified all cases requiring urgent decompression.

conclusionsCT accurately predicted MR imaging findings in patients with suspected cauda equina and nerve root compression, demonstrating its utility as an adjunct tool for patient triage in emergency settings with limited MR imaging access. This protocol could enhance the allocation of emergency resources by appropriately selecting patients for emergent MR imaging.

Indexed as

Cauda Equina SyndromeIntervertebral Disc DisplacementMagnetic Resonance ImagingSensitivity and SpecificityTomography, X-Ray ComputedAdultAgedAged, 80 and overFemaleHumansLumbar VertebraeMaleMiddle AgedProspective StudiesReproducibility of Results

Identifiers

PMID39054295
PMCPMC11392367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.