Evidence map›Paper›PMID 39054290›Full record

ArticleAJNR. American journal of neuroradiology2024

Whole-Brain Vascular Architecture Mapping Identifies Region-Specific Microvascular Profiles In Vivo.

Anja Hohmann, Ke Zhang, Christoph M Mooshage, Johann M E Jende, Lukas T Rotkopf, Heinz-Peter Schlemmer, Martin Bendszus, Wolfgang Wick, Felix T Kurz

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anja HohmannFrom the Department of Neurology (A.H., W.W.), Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-4166-5303
Ke ZhangDepartment of Diagnostic and Interventional Radiology (K.Z.), Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-7244-8483
Christoph M MooshageDepartment of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0003-3436-9298
Johann M E JendeDepartment of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-1387-9304
Lukas T RotkopfDivision of Radiology (L.T.R., H.-P.S., F.T.K.) German Cancer Research Center, Heidelberg, Germany.
Heinz-Peter SchlemmerDivision of Radiology (L.T.R., H.-P.S., F.T.K.) German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-9291-0954
Martin BendszusDepartment of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-9094-6769
Wolfgang WickFrom the Department of Neurology (A.H., W.W.), Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-6171-634X
Felix T KurzDepartment of Neuroradiology (C.M.M., J.M.E.J., M.B., F.T.K.), Heidelberg University Hospital, Heidelberg, Germany felixtobias.kurz@hug.ch.ORCID 0000-0001-7616-7147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe novel MR imaging technique of vascular architecture mapping allows in vivo characterization of local changes in cerebral microvasculature, but reference ranges for vascular architecture mapping parameters in healthy brain tissue are lacking, limiting its potential applicability as an MR imaging biomarker in clinical practice. We conducted whole-brain vascular architecture mapping in a large cohort to establish vascular architecture mapping parameter references ranges and identify region-specific cortical and subcortical microvascular profiles. MATERIALS AND

methodsThis was a single-center examination of adult patients with unifocal, stable low-grade gliomas with multiband spin- and gradient-echo EPI sequence at 3T using parallel imaging. Voxelwise plotting of resulting values for gradient-echo (R

resultsPrevalence of vascular risk factors among subjects (

conclusionsWhole-brain vascular architecture mapping in the adult brain reveals region-specific microvascular profiles. The obtained parameter reference ranges for distinct anatomic and functional brain areas may be used for future vascular architecture mapping studies on cerebrovascular pathologies and might facilitate early discovery of microvascular changes, in, eg, neurodegeneration and neuro-oncology.

Indexed as

Brain NeoplasmsMicrovesselsAdultBrainFemaleGliomaHumansMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID39054290
PMCPMC11392379

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.