Evidence map›Paper›PMID 39054278›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure.

Robel K Gebre, Alexis Moscoso Rial, Sheelakumari Raghavan, Heather J Wiste, Fiona Heeman, Alejandro Costoya-Sánchez, Christopher G Schwarz, Anthony J Spychalla, Val J Lowe, Jonathan Graff-Radford and 7 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Subtracting First Principal Component May Improve 4R Tau Detectability on [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Article
  3. Review
  4. Role ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Comparison of visual and analytic methods of Alzheimer's disease pathologic staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Robel K GebreDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Alexis Moscoso RialDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sheelakumari RaghavanDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Heather J WisteDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
Fiona HeemanDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Alejandro Costoya-SánchezUniversidade de Santiago de Compostela, Santiago de Compostela, Spain.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Anthony J SpychallaDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Ronald C PetersenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
Michael SchöllDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Melissa E MurrayDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, Minnesota; vemuri.prasanthi@mayo.edu.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI BU, GUOJUN · 1999 to 2018
$36.9M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
Investigating Resistance and Resilience Mechanisms in Alzheimer’s DiseaseR01AG056366 · NIA · MAYO CLINIC ROCHESTER · PI PRASHANTHI VEMURI · 2017 to 2026
$7.0M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
NCATS NIH HHS UL1 TR000448NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG043434NIA NIH HHS R01 AG056366NIA NIH HHS R01 AG073282NIA NIH HHS R37 AG011378NIA NIH HHS RF1 AG069052NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG024904NIBIB NIH HHS R01 EB009352NINDS NIH HHS P30 NS098577NINDS NIH HHS R01 NS097495NINDS NIH HHS UF1 NS125417
6 · The paper itself

Abstract

Alzheimer disease (AD) exhibits spatially heterogeneous 3- or 4-repeat tau deposition across participants. Our overall goal was to develop an automated method to quantify the heterogeneous burden of tau deposition into a single number that would be clinically useful.

Indexed as

Alzheimer DiseaseMachine LearningPositron-Emission Tomographytau ProteinsAgedAged, 80 and overFemaleHumansImage Processing, Computer-AssistedMaletau ProteinsAlzheimer diseasemachine learningneurologyPETsummary measuretau

Identifiers

PMID39054278
PMCPMC11372256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.