Evidence map›Paper›PMID 39054261›Full record

ArticleFEBS open bio2024

Benefits of exercise on cognitive impairment in alcohol use disorder following alcohol withdrawal.

Zhen Lyu, Zhi-Gang Gong, Min-Xia Huang, Si-Ping Xin, Mao-Zhong Zou, Yu-Quan Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhen LyuKey Lab of Aquatic Sports Training Monitoring and Intervention of General Administration of Sport of China, Faculty of Physical Education, Jiangxi Normal University, Nanchang, China.ORCID https://orcid.org/0000-0003-2812-4091
Zhi-Gang GongKey Lab of Aquatic Sports Training Monitoring and Intervention of General Administration of Sport of China, Faculty of Physical Education, Jiangxi Normal University, Nanchang, China.ORCID https://orcid.org/0000-0002-1899-6243
Min-Xia HuangScience and Technology College of Nanchang Hangkong University, Jiujiang, China.
Si-Ping XinKey Lab of Aquatic Sports Training Monitoring and Intervention of General Administration of Sport of China, Faculty of Physical Education, Jiangxi Normal University, Nanchang, China.
Mao-Zhong ZouKey Lab of Aquatic Sports Training Monitoring and Intervention of General Administration of Sport of China, Faculty of Physical Education, Jiangxi Normal University, Nanchang, China.
Yu-Quan DingKey Lab of Aquatic Sports Training Monitoring and Intervention of General Administration of Sport of China, Faculty of Physical Education, Jiangxi Normal University, Nanchang, China.

Funding

Domestic and Overseas Visiting Study Project of Jiangxi Normal UniversityGraduate Innovation Fund of Jiangxi Provincial Education Department of China YC2021-S276Science and Technology Research Project of Jiangxi Provincial Education Department of China GJJ2200337
6 · The paper itself

Abstract

Although most cognitive impairments induced by prolonged alcohol consumption tend to improve within the initial months of abstinence, there is evidence suggesting certain cognitive deficits may persist. This study aimed to investigate the impact of aerobic exercise on learning and memory in alcohol use disorder (AUD) mice following a period of abstinence from alcohol. We also sought to assess the levels of monoamine neurotransmitters in the hippocampus. To this end, we established an AUD mouse model through a two-bottle choice (sucrose fading mode and normal mode) and chronic intermittent alcohol vapor (combined with intraperitoneal injection) and randomly allocated mice into exercise groups to undergo treadmill training. Learning and memory abilities were assessed through the Morris water maze test and spontaneous activity was evaluated using the open field test. The levels of dopamine, norepinephrine, serotonin, and brain-derived neurotrophic factor in the hippocampus were quantified using enzyme-linked immunoassay (ELISA) kits. The findings reveal that after cessation of alcohol consumption, learning and memory abilities in AUD mice did not completely return to normal levels. The observed enhancement of cognitive functions in AUD mice through aerobic exercise may be attributed to restoring levels of monoamine neurotransmitters in the hippocampus, boosting brain-derived neurotrophic factor (BDNF) concentrations, and facilitating an increase in hippocampal mass. These results offer empirical evidence to support aerobic exercise as a viable therapeutic strategy to alleviate cognitive deficits associated with AUD.

Indexed as

Cognitive DysfunctionEthanolSubstance Withdrawal SyndromeAlcoholismAnimalsAnxietyBehavior, AnimalBrain-Derived Neurotrophic FactorDisease Models, AnimalHippocampusLocomotionMaleMemoryMice, Inbred C57BLPhysical Conditioning, AnimalBrain-Derived Neurotrophic FactorEthanolalcohol use disorderalcohol vapor exposureexerciselearning and memorymonoamine neurotransmitters

Identifiers

PMID39054261
PMCPMC11492329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.