Evidence map›Paper›PMID 39054240›Full record

ReviewTrends in biochemical sciences2024

Visualizing intermediate stages of viral membrane fusion by cryo-electron tomography.

Sally M Kephart, Nancy Hom, Kelly K Lee

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Frontiers in cell and developmental biology · 2026
    Review
  6. Article
  7. Review
  8. Cell fusion in osteoclastogenesis.Biochemical Society transactions · 2025
    Review
  9. Article
  10. Article
  11. Membrane-Targeting Antivirals.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sally M KephartDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Nancy HomDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Kelly K LeeDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA; Biological Structure Physics and Design Graduate Program, University of Washington, Seattle, WA, USA. Electronic address: kklee@uw.edu.

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
Structural and dynamic traits underlying phenotypic variation in HIV-1 EnvR01AI140868 · NIAID · UNIVERSITY OF WASHINGTON · PI Kelly Keisen Lee · 2019 to 2026
$5.3M
Interplay of the HIV-1 Env cytoplasmic tail, Gag-MA, and membrane: resolving molecular detail and blocking assemblyR01AI179697 · NIAID · UNIVERSITY OF WASHINGTON · PI DERDEYN, CYNTHIA ANN, GNANAKARAN, SANDRASEGARAM · 2023 to 2025
$3.1M
Lipid Bilayer Remodeling and Protein Intermediates During Membrane FusionR01AI165808 · NIAID · UNIVERSITY OF WASHINGTON · PI LEE, KELLY KEISEN · 2022 to 2025
$2.4M
NIAID NIH HHS R01 AI140868NIAID NIH HHS R01 AI165808NIAID NIH HHS R01 AI179697NIGMS NIH HHS T32 GM007750
6 · The paper itself

Abstract

Protein-mediated membrane fusion is the dynamic process where specialized protein machinery undergoes dramatic conformational changes that drive two membrane bilayers together, leading to lipid mixing and opening of a fusion pore between previously separate membrane-bound compartments. Membrane fusion is an essential stage of enveloped virus entry that results in viral genome delivery into host cells. Recent studies applying cryo-electron microscopy techniques in a time-resolved fashion provide unprecedented glimpses into the interaction of viral fusion proteins and membranes, revealing fusion intermediate states from the initiation of fusion to release of the viral genome. In combination with complementary structural, biophysical, and computation modeling approaches, these advances are shedding new light on the mechanics and dynamics of protein-mediated membrane fusion.

Indexed as

Cryoelectron MicroscopyElectron Microscope TomographyMembrane FusionVirus InternalizationHumansViral Fusion ProteinsViral Fusion Proteinscomputational modelingfusion proteinmembrane remodelingprotein-mediated membrane fusionscientific animationvirus entry

Identifiers

PMID39054240
PMCPMC11455608

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.