Evidence map›Paper›PMID 39054057›Full record

ArticleGenes & development2024

Tolerance thresholds underlie responses to DNA damage during germline development.

Gloria Jansen, Daniel Gebert, Tharini Ravindra Kumar, Emily Simmons, Sarah Murphy, Felipe Karam Teixeira

Abstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gloria JansenDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.ORCID 0000-0003-3241-6249
Daniel GebertDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.ORCID 0000-0001-6159-3231
Tharini Ravindra KumarDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
Emily SimmonsDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
Sarah MurphyDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
Felipe Karam TeixeiraDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom; fk319@cam.ac.uk.ORCID 0000-0001-7651-1657

Funding

Wellcome Trust
6 · The paper itself

Abstract

Selfish DNA modules like transposable elements (TEs) are particularly active in the germline, the lineage that passes genetic information across generations. New TE insertions can disrupt genes and impair the functionality and viability of germ cells. However, we found that in

Indexed as

DNA Breaks, Double-StrandedDNA Transposable ElementsGerm CellsAnimalsCRISPR-Cas SystemsDNA DamageDrosophila melanogasterFemaleOogenesisDNA Transposable ElementsCRISPR–Cas9DNA damagedouble-strand breakDrosophila melanogastergenome integritygermline developmenthybrid dysgenesismeiosisP-elementtransposable element

Identifiers

PMID39054057
PMCPMC11368186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.