Evidence map›Paper›PMID 39053901›Full record

ArticleEnvironmental science & technology2024

Exposome Profiling of Environmental Pollutants in Seminal Plasma and Novel Associations with Semen Parameters.

Haotian Wu, Vrinda Kalia, Katherine E Manz, Lawrence Chillrud, Nathalie Hoffmann Dishon, Gabriela L Jackson, Christian K Dye, Raoul Orvieto, Adva Aizer, Hagai Levine and 4 more

Abstract read
In one paragraph

Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. An Exploration of Machine Learning Methods in Human Biomonitoring.International journal of environmental research and public health · 2026
    Review
  3. Environmental and external stressors of postejaculatory sperm function.The Journal of reproduction and development · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haotian WuDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0002-6271-0249
Vrinda KaliaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.ORCID 0000-0003-2244-6663
Katherine E ManzSchool of Engineering, Brown University, Providence, Rhode Island 02912, United States.ORCID 0000-0002-8225-9168
Lawrence ChillrudDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Nathalie Hoffmann DishonInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan 5262000, Israel.
Gabriela L JacksonDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Christian K DyeDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Raoul OrvietoInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan 5262000, Israel.
Adva AizerInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan 5262000, Israel.
Hagai LevineBraun School of Public Health, Hadassah Medical Organization, Faculty of Medicine, Hebrew University, Jerusalem 9112102, Israel.
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Kurt D PennellSchool of Engineering, Brown University, Providence, Rhode Island 02912, United States.ORCID 0000-0002-5788-6397
Andrea A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Ronit MachtingerInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan 5262000, Israel.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
TRAINING IN ENVIRONMENTAL PATHOLOGYT32ES007272 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 1992 to 2021
$7.5M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
Principal Component Pursuit to Assess Exposure to Environmental Mixtures in Epidemiologic StudiesR01ES028805 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2018 to 2021
$2.2M
NHLBI NIH HHS T32 HL115505NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES028805NIEHS NIH HHS T32 ES007272
6 · The paper itself

Abstract

Indicators of male fertility are in decline globally, but the underlying causes, including the role of environmental exposures, are unclear. This study aimed to examine organic chemical pollutants in seminal plasma, including both known priority environmental chemicals and less studied chemicals, to identify uncharacterized male reproductive environmental toxicants. Semen samples were collected from 100 individuals and assessed for sperm concentration, percent motility, and total motile sperm. Targeted and nontargeted organic pollutant exposures were measured from seminal plasma using gas chromatography, which showed widespread detection of organic pollutants in seminal plasma across all exposure classes. We used principal component pursuit (PCP) on our targeted panel and derived one component (driven by etriadizole) associated with total motile sperm (

Indexed as

Environmental PollutantsSemenAdultEnvironmental ExposureExposomeHumansMaleEnvironmental PollutantsetridiazoleexposomefertilityNDEAnitrosaminepesticidesseminal plasmasperm

Identifiers

PMID39053901
PMCPMC11308511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.