ReviewAlcohol (Fayetteville, N.Y.)2024
Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion.
Review in Alcohol (Fayetteville, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Context-dependent effects of microglial MyD88 removal on voluntary ethanol consumption in mice.Neuropharmacology · 2026Article
- Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice.Nature neuroscience · 2026Article
- Modeling Concurrent Hedonic Disruption During Excessive Drinking and Abstinence-Related Negative Affect in a Novel Selectively Bred Mouse Line: The Crossed High Alcohol Preferring X High Drinking in the Dark (cHAPxHDID) Mice.Alcohol, clinical & experimental research · 2026Article
- The S1-insula Circuit Differentially Modulates Alcohol Drinking and Aversive Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Comparative analysis of test tube and volumetric drinking monitor methods in voluntary ethanol consumption in female mice for prenatal alcohol exposure.Toxicology reports · 2026Article
- Association of stress-sensitive mid-insula activity with alcohol drinking and negative affect-like behavior during abstinence in mice.Neuropharmacology · 2026Article
- Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning.Psychopharmacology · 2026Article
- Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males.Translational psychiatry · 2026Article
- Patterns of chronic ethanol drinking in male and female cynomolgus monkeys.Alcohol, clinical & experimental research · 2026Article
- The Psychedelic Psilocin Suppresses Activity of Central Amygdala Corticotropin-Releasing Factor Receptor 1 Neurons and Decreases Ethanol Drinking in Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Chronic alcohol drinking delays recovery from capsaicin- and nerve injury-induced hypersensitivity in mice.Alcohol (Fayetteville, N.Y.) · 2025Article
- Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males.bioRxiv : the preprint server for biology · 2025Article
- Chronic alcohol drinking delays recovery from capsaicin- and nerve injury-induced hypersensitivity in mice.bioRxiv : the preprint server for biology · 2025Article
- High-throughput quantitation of acetaldehyde and ethanol in mice using gas chromatography/mass spectrometry positive chemical ionization.Alcohol, clinical & experimental research · 2025Article
- Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward.Biology of sex differences · 2025Article
- Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review.Alcohol, clinical & experimental research · 2025Review
- Prenatal methadone exposure produces functional and molecular alterations in the basolateral amygdala and decreased voluntary ethanol intake in female, but not male offspring.Frontiers in behavioral neuroscience · 2025Article
- Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents.Addiction neuroscience · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Alcohol Use Disorder (AUD) is a growing problem worldwide, causing an incredible burden on health and the economy. Though AUD impacts people of all backgrounds and demographics, increasing evidence has suggested robust sex differences in alcohol drinking patterns and AUD-induced negative emotionality or hyperkatifeia. Rates of problematic drinking have significantly risen among women, and women face more severe negative emotional consequences in abstinence such as increased risk of comorbidity with an anxiety or mood disorder and more severe symptoms of depression. As such, a bevy of preclinical literature using contingent methods of alcohol (ethanol) consumption has amassed in recent years to better understand sex as a biological variable in alcohol drinking and abstinence-induced negative emotionality. Mice are widely used to model alcohol drinking, as they are conducive to genetic manipulation strategies, and many strains will voluntarily consume alcohol. Sex-specific results from these mouse studies, however, have been inconsistent. Therefore, this review aims to summarize the current knowledge on sex differences in AUD-related contingent ethanol drinking and abstinence-induced negative emotionality in mice. Various contingent mouse drinking models and negative emotional-based behavioral paradigms are introduced and subsequently discussed in the context of sex differences to show increasing indications of sex specificity in mouse preclinical studies of AUD. With this review, we hope to inform future research on potential sex differences in preclinical mouse models of AUD and provide mounting evidence supporting the need for more widespread inclusion of preclinical female subjects in future studies.
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