Evidence map›Paper›PMID 39053449›Full record

ArticleThe Journal of international medical research2024

Integrative genomic analysis reveals cancer-associated mutations in patients with ophthalmic tumors.

Fengjiao Zhu, Pengpeng Wang, Zhiyuan Zhang, Chunlei Yao, Yijie Wang, Juan Ye, Jian Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fengjiao ZhuMyGenostics Inc., Beijing, China.ORCID 0000-0001-9552-3135
Pengpeng WangMyGenostics Inc., Beijing, China.
Zhiyuan ZhangMyGenostics Inc., Beijing, China.
Chunlei YaoDepartment of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yijie WangDepartment of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Juan YeDepartment of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jian WuMyGenostics Inc., Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveApart from the role of the retinoblastoma gene, the genomic events associated with poor outcomes in patients with ophthalmic tumors are poorly understood.

methodsWe retrospectively analyzed 48 patients with six types of ophthalmic tumors. We searched for high-frequency mutated genes and susceptibility genes in these patients using combined exome and transcriptome analysis.

resultsWe identified four clearly causative genes (

conclusions

Indexed as

Eye NeoplasmsGenomicsMutationTumor Suppressor Protein p53AdultAgedBiomarkers, TumorCore Binding Factor Alpha 2 SubunitDNA Topoisomerases, Type IIFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansMaleMiddle AgedBAP1 protein, humanBiomarkers, TumorCore Binding Factor Alpha 2 SubunitDNA Topoisomerases, Type IIPatched-1 ReceptorPhosphatidylinositol 3-KinasesPoly-ADP-Ribose Binding ProteinsProto-Oncogene Proteins c-aktPTCH1 protein, humanRUNX1 protein, humanSmoothened ReceptorSMO protein, humanTOP2A protein, humanTP53 protein, humanTumor Suppressor Protein p53Tumor Suppressor ProteinsUbiquitin ThiolesteraseExon sequencingophthalmic tumorPI3K-Akt signaling pathwayRNA-Seqsusceptibility geneTP53

Identifiers

PMID39053449
PMCPMC11283671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.