Evidence map›Paper›PMID 39053213›Full record

ArticlePsychiatry research2024

Long-latency auditory evoked response amplitudes at first episode of psychosis predict six-month recovery in positive symptom severity.

Brian A Coffman, Mark Curtis, Dylan Seebold, Jenay Kocsis, Aseem Dani, Fran López-Caballero, Alfredo Sklar, Dean F Salisbury

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian A CoffmanClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: CoffmanB@upmc.edu.
Mark CurtisClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dylan SeeboldClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jenay KocsisClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Aseem DaniClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Fran López-CaballeroClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alfredo SklarClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dean F SalisburyClinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

Auditory Cortex Connectivity in Emerging PsychosisR01MH113533 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALISBURY, DEAN F · 2017 to 2021
$3.4M
Auditory Attention in First Episode PsychosisR01MH108568 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALISBURY, DEAN F · 2016 to 2021
$3.1M
Visual Network Connectivity and Perceptual Modulation in Early PsychosisK23MH127389 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Alfredo Luis Sklar · 2022 to 2026
$941k
NIMH NIH HHS K23 MH127389NIMH NIH HHS R01 MH108568NIMH NIH HHS R01 MH113533
6 · The paper itself

Abstract

Predicting treatment response would facilitate individualized medical treatment in first-episode psychosis (FEP). We examined relationships between auditory-evoked M100 and longitudinal change in positive symptoms in FEP. M100 was measured from source-resolved magnetoencephalography and symptoms were assessed at initial contact and six months later. M100 at baseline significantly predicted symptom change. Larger M100 at baseline predicted symptom improvement, as did shorter untreated psychosis. Shorter untreated psychosis also correlated with larger M100, and M100 mediated the effect of untreated psychosis on treatment response. Thus, M100 may provide a proximal and objective index of untreated psychosis and a viable route to individualized medicine.

Indexed as

Evoked Potentials, AuditoryMagnetoencephalographyPsychotic DisordersAdolescentAdultFemaleHumansMaleYoung Adult

Identifiers

PMID39053213
PMCPMC11321909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.