Evidence map›Paper›PMID 39052773›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Low-dose orthotopic cancer implantation permits measurement of longitudinal functional changes associated with cachexia.

Ishan Roy, Benjamin Binder-Markey, Amber Willbanks, Danielle Sychowski, Tenisha Phipps, Addison Barber, Donna McAllister, Dominic D'Andrea, Colin K Franz, Rajeswari Pichika and 2 more

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ishan RoyShirley Ryan AbilityLab, Chicago, Illinois, United States.ORCID 0000-0002-9109-0421
Benjamin Binder-MarkeyDepartment of Physical Therapy and Rehabilitation Sciences, Drexel, University, Philadelphia, Pennsylvania, United States.ORCID 0000-0001-8920-4381
Amber WillbanksShirley Ryan AbilityLab, Chicago, Illinois, United States.
Danielle SychowskiShirley Ryan AbilityLab, Chicago, Illinois, United States.
Tenisha PhippsShirley Ryan AbilityLab, Chicago, Illinois, United States.
Addison BarberShirley Ryan AbilityLab, Chicago, Illinois, United States.
Donna McAllisterDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Dominic D'AndreaShirley Ryan AbilityLab, Chicago, Illinois, United States.
Colin K FranzShirley Ryan AbilityLab, Chicago, Illinois, United States.ORCID 0000-0003-4546-8638
Rajeswari PichikaShirley Ryan AbilityLab, Chicago, Illinois, United States.
Michael B DwinellDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0001-5372-633X
Richard L LieberShirley Ryan AbilityLab, Chicago, Illinois, United States.ORCID 0000-0002-7203-4520

Funding

Biased chemokine receptor signaling in cancer progressionR01CA226279 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MICHAEL B · 2019 to 2023
$1.9M
Muscle Fibrosis in CachexiaK08AR081391 · NIAMS · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI Ishan Roy · 2022 to 2026
$846k
RR&D Senior Research Career Scientist Award ApplicationIK6RX003351 · VA · EDWARD HINES JR VA HOSPITAL · PI LIEBER, RICHARD L. · 2020 to 2025
–
NCI NIH HHS R01 CA226279NIAMS NIH HHS K08 AR081391RRD VA IK6 RX003351
6 · The paper itself

Abstract

Progressive functional decline is a key element of cancer-associated cachexia. Major barriers to translating preclinical therapies into the clinic include lack of cancer models that accurately mimic functional decline, which develops over time, and use of nonspecific measures, like grip strength, as surrogates for physical function. In this study, we aimed to extend the survival and longevity of a cancer model, to investigate cachexia-related function at the basic science level. Survival extension studies were performed by testing multiple cell lines, dilutions, and vehicle-types in orthotopic implantation of K-ras

Indexed as

CachexiaMuscle, SkeletalAnimalsCell Line, TumorDisease Models, AnimalFemaleHand StrengthMaleMiceMuscular AtrophyNeoplasmsmuscle wastingpancreatic neoplasmphysical functional performancerehabilitation

Identifiers

PMID39052773
PMCPMC11424168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.