Evidence map›Paper›PMID 39052744›Full record

ArticleThe Journal of infectious diseases2024

Estimating the Potential Public Health Value of BCG Revaccination.

Rebecca A Clark, Tom Sumner, Chathika K Weerasuriya, Roel Bakker, Thomas J Scriba, Richard G White

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. BCG Revaccination for the Prevention ofThe New England journal of medicine · 2025
    Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rebecca A ClarkTB Modelling Group and TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0001-8923-0301
Tom SumnerTB Modelling Group and TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0001-9305-534X
Chathika K WeerasuriyaTB Modelling Group and TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0001-7364-1026
Roel BakkerTB Modelling Group and TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-1958-0944
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative (SATVI), Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0641-1359
Richard G WhiteTB Modelling Group and TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0003-4410-6635

Funding

Engineering and Physical Sciences Research Council EP/P020267/1University of Edinburgh
6 · The paper itself

Abstract

An upcoming trial may provide further evidence that adolescent/adult-targeted BCG revaccination prevents sustained Mycobacterium tuberculosis infection, but its public health value depends on its impact on overall tuberculosis morbidity and mortality, which will remain unknown. Using previously calibrated models for India and South Africa, we simulated BCG revaccination assuming 45% prevention-of-infection efficacy, and we evaluated scenarios varying additional prevention-of-disease efficacy between +50% (reducing risk) and -50% (increasing risk). Given the assumed prevention-of-infection efficacy and range in prevention-of-disease efficacy, BCG revaccination may have a positive health impact and be cost-effective. This may be useful when considering future evaluations and implementation of adolescent/adult BCG revaccination.

Indexed as

BCG VaccineImmunization, SecondaryPublic HealthTuberculosisAdolescentAdultChildChild, PreschoolCost-Benefit AnalysisHumansIndiaInfantMycobacterium tuberculosisSouth AfricaYoung AdultBCG VaccineBCG revaccinationhealth and economic impactmathematical modellingtuberculosisvaccines

Identifiers

PMID39052744
PMCPMC11272081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.