ArticleThe Journal of infectious diseases2024
Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada.
Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Maternal RSVpreF Vaccine Effectiveness Against Respiratory Syncytial Virus in Hospitalized Infants.JAMA pediatrics · 2026Article
- Vertical Vaccination Against Infant Influenza Hospitalization in a Tropical Setting.JAMA network open · 2026Article
- Global vaccine development.Nature medicine · 2026Review
- Maternal influenza vaccination intention and associated factors among pregnant women in Guizhou Province, China.Human vaccines & immunotherapeutics · 2025Article
- Are Online Maps and Booking Systems for Antenatal Vaccination Fit for Purpose? A Qualitative Study.Vaccines · 2025Article
- Influenza Vaccination During Pregnancy and Infant Influenza in the First 6 Months of Life.Obstetrics and gynecology · 2025Article
- Preventing Influenza Virus Infection and Severe Influenza Among Pregnant People and Infants.Journal of women's health (2002) · 2024Article
Corrections and comments
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Authors and funding
24 authors.
Funding
Abstract
backgroundRandomized trials conducted in low- and middle-income settings demonstrated efficacy of influenza vaccination during pregnancy against influenza infection among infants <6 months of age. However, vaccine effectiveness (VE) estimates from settings with different population characteristics and influenza seasonality remain limited.
methodsWe conducted a test-negative study in Ontario, Canada. All influenza virus tests among infants <6 months from 2010 to 2019 were identified and linked with health databases to ascertain information on maternal-infant dyads. VE was estimated from the odds ratio for influenza vaccination during pregnancy among cases versus controls, computed using logistic regression with adjustment for potential confounders.
resultsAmong 23 806 infants tested for influenza, 1783 (7.5%) were positive and 1708 (7.2%) were born to mothers vaccinated against influenza during pregnancy. VE against laboratory-confirmed infant influenza infection was 64% (95% confidence interval [CI], 50%-74%). VE was similar by trimester of vaccination (first/second, 66% [95% CI, 40%-80%]; third, 63% [95% CI, 46%-74%]), infant age at testing (0 to <2 months, 63% [95% CI, 46%-75%]; 2 to <6 months, 64% [95% CI, 36%-79%]), and gestational age at birth (≥37 weeks, 64% [95% CI, 50%-75%]; < 37 weeks, 61% [95% CI, 4%-86%]). VE against influenza hospitalization was 67% (95% CI, 50%-78%).
conclusionsInfluenza vaccination during pregnancy offers effective protection to infants <6 months, for whom vaccines are not currently available.
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