Evidence map›Paper›PMID 39052701›Full record

Trial reportThe Journal of infectious diseases2024

Differences in Rotavirus Shedding and Duration by Infant Oral Rotavirus Vaccination Status in Dhaka, Bangladesh, 2011-2014.

Jenna Ciszewski, Mami Taniuchi, Benjamin Lee, E Ross Colgate, James A Platts-Mills, Rashidul Haque, K Zaman, Benjamin Lopman, William A Petri, Beth D Kirkpatrick and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01375647 (Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01375647 phase3completednot on this map

Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh

TypeinterventionalSponsorUniversity of VermontRan2011 to 2014Enrolled700ConditionsRotavirus Diarrhea, Vaccine Virus Shedding, Tropical EnteropathyArmsIPV (inactivated polio vaccine), Rotarix
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jenna CiszewskiDepartment of Epidemiology, Emory University, Atlanta, Georgia, USA.
Mami TaniuchiDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Benjamin LeeDepartment of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
E Ross ColgateDepartment of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
James A Platts-MillsDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Rashidul HaqueInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
K ZamanInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Benjamin LopmanDepartment of Epidemiology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-9238-0068
William A PetriDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Beth D KirkpatrickDepartment of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Elizabeth T Rogawski McQuadeDepartment of Epidemiology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-4942-3747

Funding

Translation of epidemiologic findings in enteric disease to public health actionK01AI130326 · NIAID · UNIVERSITY OF VIRGINIA · PI ROGAWSKI MCQUADE, ELIZABETH TACKET · 2018 to 2022
$612k
Bill and Melinda Gates Foundation OPP1017093National Institute of Allergy and Infectious DiseasesNIAID NIH HHS K01 AI130326NIH HHS K01AI130326
6 · The paper itself

Abstract

To evaluate how breakthrough rotavirus disease contributes to transmission, we examined the impact of rotavirus vaccination on fecal shedding and duration of illness. We used multivariable linear regression to analyze rotavirus quantity by RT-qPCR and duration among 184 episodes of rotavirus diarrhea positive by ELISA in the PROVIDE study. Vaccinated children had less fecal viral shedding compared to unvaccinated children (mean difference = -0.59 log copies per gram of stool; 95% confidence interval [CI], -.99 to -.19). Duration of illness was on average 0.47 days (95% CI, -.23 to 1.17 days) shorter among vaccinated children. Rotarix vaccination reduces shedding burden among breakthrough cases of rotavirus gastroenteritis. Clinical Trials Registration . NCT01375647.

Indexed as

FecesRotavirusRotavirus InfectionsRotavirus VaccinesVaccines, AttenuatedVirus SheddingAdministration, OralBangladeshDiarrheaFemaleGastroenteritisHumansInfantMaleVaccinationRIX4414 vaccineRotavirus VaccinesVaccines, Attenuateddiarrheaenteric infectionsrotavirusvaccination

Identifiers

PMID39052701
PMCPMC11272065

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.