Evidence map›Paper›PMID 39052580›Full record

SynthesisPloS one2024

Burden of early neonatal mortality in Sub-Saharan Africa. A systematic review and meta-analysis.

Natnael Moges, Anteneh Mengist Dessie, Denekew Tenaw Anley, Melkamu Aderajew Zemene, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizachew Ambaw Kassie, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Endeshaw Chekol Abebe and 8 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Natnael MogesDepartment of Pediatrics and Child Health Nursing, College of Health sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0002-1274-5857
Anteneh Mengist DessieDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Denekew Tenaw AnleyDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Melkamu Aderajew ZemeneDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Natnael Atnafu GebeyehuDepartment of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
Getachew Asmare AdellaDepartment of Reproductive Health and Nutrition, School of Public Health, Woliata Sodo University, Woliata Sodo, Ethiopia.
Gizachew Ambaw KassieDepartment of Epidemiology and Biostatistics, School of Public Health, Woliata Sodo University, Woliata Sodo, Ethiopia.ORCID 0000-0003-0736-5769
Misganaw Asmamaw MengstieDepartment of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Mohammed Abdu SeidUnit of Physiology, Department of Biomedical Science, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Endeshaw Chekol AbebeDepartment of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Molalegn Mesele GeseseDepartment of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
Yenealem Solomon KebedeDepartment of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Sefineh Fenta FelekeDepartment of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Tadesse Asmamaw DejenieDepartment of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Natnael Amare TesfaSchool of Medicine, College of Health Science, Woldia University, Woldia, Ethiopia.
Wubet Alebachew BayihDepartment of Pediatrics and Child Health Nursing, College of Health sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Ermias Sisay ChanieDepartment of Pediatrics and Child Health Nursing, College of Health sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Berihun BantieDepartment of Comprehensive Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlobally, with a neonatal mortality rate of 27/1000 live births, Sub-Saharan Africa has the highest rate in the world and is responsible for 43% of all infant fatalities. In the first week of life, almost three-fourths of neonatal deaths occur and about one million babies died on their first day of life. Previous studies lack conclusive evidence regarding the overall estimate of early neonatal mortality in Sub-Saharan Africa. Therefore, this review aimed to pool findings reported in the literature on magnitude of early neonatal mortality in Sub-Saharan Africa.

methodsThis review's output is the aggregate of magnitude of early neonatal mortality in sub-Saharan Africa. Up until June 8, 2023, we performed a comprehensive search of the databases PubMed/Medline, PubMed Central, Hinary, Google, Cochrane Library, African Journals Online, Web of Science, and Google Scholar. The studies were evaluated using the JBI appraisal check list. STATA 17 was employed for the analysis. Measures of study heterogeneity and publication bias were conducted using the I2 test and the Eggers and Beggs tests, respectively. The Der Simonian and Laird random-effect model was used to calculate the combined magnitude of early neonatal mortality. Besides, subgroup analysis, sensitivity analysis, and meta regression were carried out to identify the source of heterogeneity.

resultsFourteen studies were included from a total of 311 articles identified by the search with a total of 278,173 participants. The pooled magnitude of early neonatal mortality in sub-Saharan Africa was 80.3 (95% CI 66 to 94.6) per 1000 livebirths. Ethiopia had the highest pooled estimate of early neonatal mortality rate, at 20.1%, and Cameroon had the lowest rate, at 0.5%. Among the included studies, both the Cochrane Q test statistic (χ2 = 6432.46, P <0.001) and I2 test statistic (I2 = 99.80%, p <0.001) revealed statistically significant heterogeneity. Egger's weighted regression (p <0.001) and funnel plot show evidence of publication bias in this meta-analysis.

conclusionThis review demonstrated that the pooled magnitude of early neonatal mortality in sub-Saharan Africa is substantial. Therefore, governmental and nongovernmental agencies, international organizations, healthcare providers and institutions and academic and research institutions should give a due attention and design strategies to reduce early neonatal mortality in Sub-Saharan Africa.

Indexed as

Infant MortalityAfrica South of the SaharaFemaleHumansInfantInfant, Newborn

Identifiers

PMID39052580
PMCPMC11271883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.