ArticleBrain structure & function2024
Functional and structural brain connectivity in disorders of consciousness.
Article in Brain structure & function, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Multimodal Assessment of Consciousness with Brain-Computer Interfaces and Artificial Intelligence: From Acquired Brain Injury to Neurodegenerative Disease.Journal of clinical medicine · 2026Review
- Multimodal multicentre investigation of diagnostic and prognostic markers in disorders of consciousness.Brain : a journal of neurology · 2026Article
- Pleasant odors specifically promote a soothing autonomic response and brain-body coupling through respiratory modulation.Scientific reports · 2025Article
- Electroencephalographic characteristics of transcutaneous auricular vagus nerve stimulation for prolonged disorders of consciousness: a study protocol.Frontiers in neuroscience · 2025Article
- Graph models of brain state in deep anesthesia reveal sink state dynamics of reduced spatiotemporal complexity.Network neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Brain connectivity, allowing information to be shared between distinct cortical areas and thus to be processed in an integrated way, has long been considered critical for consciousness. However, the relationship between functional intercortical interactions and the structural connections thought to underlie them is poorly understood. In the present work, we explore both functional (with an EEG-based metric: the median weighted symbolic mutual information in the theta band) and structural (with a brain MRI-based metric: fractional anisotropy) connectivities in a cohort of 78 patients with disorders of consciousness. Both metrics could distinguish patients in a vegetative state from patients in minimally conscious state. Crucially, we discovered a significant positive correlation between functional and structural connectivities. Furthermore, we showed that this structure-function relationship is more specifically observed when considering structural connectivity within the intra- and inter-hemispheric long-distance cortico-cortical bundles involved in the Global Neuronal Workspace (GNW) theory of consciousness, thus supporting predictions of this model. Altogether, these results support the interest of multimodal assessments of brain connectivity in refining the diagnostic evaluation of patients with disorders of consciousness.
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Registered trials
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