Evidence map›Paper›PMID 39052094›Full record

ArticleBrain structure & function2024

Structural reorganization of medullary dorsal horn astrocytes in a rat model of neuropathic pain.

Yi Sul Cho, Do Hyoung Kim, Jin Young Bae, Jo Young Son, Jong-Heon Kim, Ruqayya Afridi, Kyoungho Suk, Dong Kuk Ahn, Yong Chul Bae

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Article in Brain structure & function, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi Sul Cho *Department of Anatomy, Physiology and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
Do Hyoung Kim *Department of Anatomy, Physiology and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
Jin Young BaeDepartment of Anatomy, Physiology and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
Jo Young SonDepartment of Anatomy, Physiology and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
Jong-Heon KimBrain Science & Engineering Institute, Kyungpook National University, Daegu, Republic of Korea.
Ruqayya AfridiDepartment of Pharmacology, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kyoungho SukBrain Science & Engineering Institute, Kyungpook National University, Daegu, Republic of Korea.
Dong Kuk AhnDepartment of Anatomy, Physiology and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea. dkahn@knu.ac.kr.
Yong Chul BaeDepartment of Anatomy, Physiology and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea. ycbae@knu.ac.kr.

Funding

National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIT) NRF-2017R1A5A2015391
6 · The paper itself

Abstract

Multiple studies have shown that astrocytes in the medullary dorsal horn (MDH) play an important role in the development of pathologic pain. However, little is known about the structural reorganization of the peripheral astrocytic processes (PAP), the main functional part of the astrocyte, in MDH in neuropathic state. For this, we investigated the structural relationship between PAP and their adjacent presynaptic axon terminals and postsynaptic dendrites in the superficial laminae of the MDH using electron microscopical immunohistochemistry for ezrin, a marker for PAP, and quantitative analysis in a rat model of neuropathic pain following chronic constriction injury of the infraorbital nerve (CCI-ION). We found that, compared to controls, in rats with CCI-ION, (1) the number, % area, surface density, and volume fraction of ezrin-positive (+) PAP, as well as the fraction of synaptic edge apposed by ezrin + PAP and the degree of its coverage of presynaptic axon terminals and postsynaptic dendrites increased significantly, (2) these effects were abolished by administration of the mGluR5 antagonist 2-methyl-6-(phenylethynyl) pyridine (MPEP). These findings indicate that PAP undergoes structural reorganization around the central synapses of sensory afferents following nerve injury, suggest that it may be mediated by mGluR5, and may represent the structural basis for enhancing astrocyte-neuron interaction in neuropathic pain.

Indexed as

AstrocytesDisease Models, AnimalNeuralgiaRats, Sprague-DawleySpinal Cord Dorsal HornAnimalsCytoskeletal ProteinsDendritesEzrinMaleMedulla OblongataPresynaptic TerminalsRatsReceptor, Metabotropic Glutamate 5Cytoskeletal ProteinsEzrinReceptor, Metabotropic Glutamate 5EzrinNerve injuryNeuropathic painPeripheral astrocytic processStructural remodeling

Identifiers

PMID39052094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.