Evidence map›Paper›PMID 39052000›Full record

ArticleeLife2024

A syngeneic spontaneous zebrafish model of

Alex Weiss, Cassandra D'Amata, Bret J Pearson, Madeline N Hayes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alex WeissDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Cassandra D'AmataDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Bret J PearsonDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0002-3473-901X
Madeline N HayesDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada.ORCID https://orcid.org/0000-0002-0089-8995

Funding

Mechanisms of cell corpse clearance in tissue turnover and regeneration using planarians and zebrafishR01GM155244 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bret James Pearson · 2024 to 2026
$1.0M
CIHR FellowshipCIHR PJT-159611Hospital for Sick Children Start-up FundsNIGMS NIH HHS R01 GM155244NIH HHS 1R01GM155244Ontario Institute for Cancer Research IA-026Oregon Health and Science University Start-up Funds
6 · The paper itself

Abstract

High-throughput vertebrate animal model systems for the study of patient-specific biology and new therapeutic approaches for aggressive brain tumors are currently lacking, and new approaches are urgently needed. Therefore, to build a patient-relevant in vivo model of human glioblastoma, we expressed common oncogenic variants including activated human EGFR

Indexed as

Brain NeoplasmsDisease Models, AnimalErbB ReceptorsGlioblastomaInflammationTumor Suppressor Protein p53ZebrafishZebrafish ProteinsAnimalsHumansTumor Microenvironmentepidermal growth factor receptor VIIIErbB Receptorstp53 protein, zebrafishTumor Suppressor Protein p53Zebrafish Proteinscancer biologycancer variant modelingcell biologyglioblastomainflammationtumor microenvironmentzebrafish

Identifiers

PMID39052000
PMCPMC11272161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.