Evidence map›Paper›PMID 39051878›Full record

ArticleRadiology. Cardiothoracic imaging2024

Characterizing Lung Parenchymal Aeration via Standardized Signal Intensity from Free-breathing 4D Dynamic MRI in Phantoms, Healthy Children, and Pediatric Patients with Thoracic Insufficiency Syndrome.

Yubing Tong, Jayaram K Udupa, Joseph M McDonough, Caiyun Wu, Lipeng Xie, Chamith S Rajapakse, Samantha Gogel, Sulagna Sarkar, Oscar H Mayer, Jason B Anari and 2 more

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Article in Radiology. Cardiothoracic imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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5 citing papers in PubMed.

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5 · Who and what money

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12 authors.

Yubing TongFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).ORCID 0000-0002-2133-4910
Jayaram K UdupaFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).ORCID 0000-0002-7361-2927
Joseph M McDonoughFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).
Caiyun WuFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).ORCID 0000-0002-4351-7697
Lipeng XieFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).ORCID 0000-0002-9632-6982
Chamith S RajapakseFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).
Samantha GogelFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).ORCID 0009-0009-3752-9155
Sulagna SarkarFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).
Oscar H MayerFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).
Jason B AnariFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).
Drew A TorigianFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).ORCID 0000-0001-8999-9735
Patrick J CahillFrom Department of Radiology, the Medical Image Processing Group, University of Pennsylvania, 3710 Hamilton Walk, Goddard Bldg, 6th Fl, Philadelphia, PA 19104 (Y.T., J.K.U., C.W., L.X., D.A.T.); The Wyss/Campbell Center for Thoracic Insufficiency Syndrome, The Children's Hospital of Philadelphia, Philadelphia, Pa (J.M.D., S.G., S.S., J.B.A., P.J.C.); Departments of Radiology and Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pa (C.S.R.); and Division of Pulmonology, The Children's Hospital of Philadelphia, Philadelphia, Pa (O.H.M.).

Funding

Virtual growing child 5-dimensional functional models for treating respiratory anomaliesR01HL150147 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI TORIGIAN, DREW, UDUPA, JAYARAM K · 2020 to 2023
$3.1M
NHLBI NIH HHS R01 HL150147
6 · The paper itself

Abstract

Purpose To investigate free-breathing thoracic bright-blood four-dimensional (4D) dynamic MRI (dMRI) to characterize aeration of parenchymal lung tissue in healthy children and patients with thoracic insufficiency syndrome (TIS). Materials and Methods All dMR images in patients with TIS were collected from July 2009 to June 2017. Standardized signal intensity (sSI) was investigated, first using a lung aeration phantom to establish feasibility and sensitivity and then in a retrospective research study of 40 healthy children (16 male, 24 female; mean age, 9.6 years ± 2.1 [SD]), 20 patients with TIS before and after surgery (11 male, nine female; mean age, 6.2 years ± 4.2), and another 10 healthy children who underwent repeated dMRI examinations (seven male, three female; mean age, 9 years ± 3.6). Individual lungs in 4D dMR images were segmented, and sSI was assessed for each lung at end expiration (EE), at end inspiration (EI), preoperatively, postoperatively, in comparison to normal lungs, and in repeated scans. Results Air content changes of approximately 6% were detectable in phantoms via sSI. sSI within phantoms significantly correlated with air occupation (Pearson correlation coefficient = -0.96 [

Indexed as

LungMagnetic Resonance ImagingPhantoms, ImagingChildChild, PreschoolFemaleHumansImaging, Three-DimensionalMaleRespirationRespiratory InsufficiencyRetrospective StudiesSyndromeFree-breathing Dynamic MRILungLung Parenchymal AerationMRI Intensity StandardizationMR ImagingPediatricsThoracic Insufficiency SyndromeThoracic SurgeryThorax

Identifiers

PMID39051878
PMCPMC11369656

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