Evidence map›Paper›PMID 39051732›Full record

ArticleJournal of animal science2024

Effect of zearalenone on the jejunum of weaned gilts through the Epac1/Rap1/JNK pathway.

Heng Liu, Lulu Ma, Jiawei Fu, Xiangyu Ma, Yufei Gao, Yiping Xie, Xuejun Yuan, Yuxi Wang, Weiren Yang, Shuzhen Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heng LiuKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Lulu MaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Jiawei FuKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Xiangyu MaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Yufei GaoKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Yiping XieKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Xuejun YuanCollege of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.
Yuxi WangAgriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB, Canada.
Weiren YangKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Shuzhen JiangKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zearalenone (ZEN) is a nonsteroidal estrogenic mycotoxin produced by Fusarium strains that is harmful to the intestinal health of animals and is widely present in contaminated crops. The objective of this study was to investigate the potential therapeutic target of ZEN-induced jejunal damage in weaned gilts. Sixteen weaned gilts either received a basal diet or a basal diet supplemented with 3.0 mg/kg ZEN in a 32-d experiment. The results showed that ZEN at the concentration of 3.0 mg/kg diet activated the inflammatory response and caused oxidative stress of gilts (P < 0.05). ZEN exposure resulted in the upregulation (P < 0.05) of the Exchange protein directly activated by the cAMP 1/Ras-related protein1/c-Jun N-terminal kinase (Epac1/Rap1/JNK) signaling pathway in the jejunum of gilts in vivo and in the intestinal porcine epithelial cells in vitro. The cell viability, EdU-positive cells, and the mRNA expression of B-cell lymphoma-2 (Bcl-2) were decreased, whereas the reactive oxygen species production and the mRNA expressions of Bcl-2-associated X (Bax) and Cysteine-aspartic acid protease 3 (Caspase3) were increased (P < 0.05) by ZEN. However, ZEN increased the mRNA expression of Bcl-2 and decreased the mRNA expressions of Bax and caspase3 (P < 0.05) after the Epac1 was blocked. These results collectively indicated that a 3.0 mg ZEN /kg diet induced jejunal damage via the Epac1/Rap1/JNK signaling pathway.

Indexed as

JejunumZearalenoneAnimal FeedAnimalsDietEstrogens, Non-SteroidalFemaleGuanine Nucleotide Exchange FactorsMAP Kinase Signaling SystemOxidative StressSignal TransductionSwineWeaningEstrogens, Non-SteroidalGuanine Nucleotide Exchange FactorsZearalenoneEpac1/Rap1/JNK signaling pathwaygiltsintestinal porcine epithelial cellsjejunumzearalenone

Identifiers

PMID39051732
PMCPMC11367561

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.