ArticleJNCI cancer spectrum2024
Neighborhood-level social determinants of health burden among adolescent and young adult cancer patients and impact on overall survival.
Article in JNCI cancer spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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5 citing papers in PubMed.
- A decomposition analysis to evaluate the role of social, chemical, and neighborhood factors on the Black/White disparity in preterm birth in Greater Houston, Texas.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Differential associations between social determinants of health and the initiation of medications for opioid use disorder across care settings.npj health systems · 2026Article
- Built and socioeconomic environment: associations with cancer-risk health behaviors among healthy emerging adults.Journal of behavioral medicine · 2026Article
- The role of rurality and race/ethnicity in thyroid cancer stage at diagnosis and survival among adolescents and young adults in the United States: an analysis of 2000-2021 SEER data.Cancer causes & control : CCC · 2026Article
- Effects of Neighborhood Deprivation Index on Survival in Gastroesophageal Adenocarcinoma.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
backgroundNeighborhood socioeconomic deprivation has been linked to adverse health outcomes, yet it is unclear whether neighborhood-level social determinants of health (SDOH) measures affect overall survival in adolescent and young adult patients with cancer.
methodsThis study used a diverse cohort of adolescent and young adult patients with cancer (N = 10 261) seen at MD Anderson Cancer Center. Zip codes were linked to Area Deprivation Index (ADI) values, a validated neighborhood-level SDOH measure, with higher ADI values representing worse SDOH.
resultsADI was statistically significantly worse (P < .050) for Black (61.7) and Hispanic (65.3) patients than for White patients (51.2). Analysis of ADI by cancer type showed statistically significant differences, mainly driven by worse ADI in patients with cervical cancer (62.3) than with other cancers. In multivariable models including sex, age at diagnosis, cancer diagnosis, and race and ethnicity, risk of shorter survival for people residing in neighborhoods with the least favorable ADI quartile was greater than for individuals in the most favorable ADI quartile (hazard ratio = 1.09, 95% confidence interval = 1.00 to 1.19, P = .043).
conclusionAdolescent and young adult patients with cancer and the worst ADI values experienced a nearly 10% increase in risk of dying than patients with more favorable ADI values. This effect was strongest among White adolescent and young adult survivors. Although the magnitude of the effect of ADI on survival was moderate, the presence of a relationship between neighborhood-level SDOH and survival among patients who received care at a tertiary cancer center suggests that ADI is a meaningful predictor of survival. These findings provide intriguing evidence for potential interventions aimed at supporting adolescent and young adult patients with cancer from disadvantaged neighborhoods.
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