Evidence map›Paper›PMID 39051482›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Qiu Chen, Hong Xiao, Lijun Hu, Yongquan Huang, Zhong Cao, Xintao Shuai, Zhongzhen Su

Erratum issuedAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  12. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Qiu ChenDepartment of Ultrasound, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, P. R. China.
Hong XiaoDepartment of Medical Ultrasonic, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, P. R. China.
Lijun HuDepartment of Ultrasound, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, P. R. China.
Yongquan HuangDepartment of Ultrasound, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, P. R. China.
Zhong CaoSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107, P. R. China.ORCID 0000-0003-4004-1037
Xintao ShuaiNanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, P. R. China.ORCID 0000-0003-4271-0310
Zhongzhen SuDepartment of Ultrasound, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, P. R. China.ORCID 0000-0002-7281-7357

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515010716Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515013242Guangdong Basic Research Center of Excellence for Functional Molecular Engineering 31000-42080001Longhua District Science and Innovation Commission Project Grants of Shenzhen 10162A20221027B1FA526National Natural Science Foundation of China 31971296National Natural Science Foundation of China 52073313National Natural Science Foundation of China 82072038National Natural Science Foundation of China 82302360National Natural Science Foundation of China 8237070776National Natural Science Foundation of China 82371975Shenzhen Science and Technology Program 2023A002Shenzhen Science and Technology Program KCXFZ 202002011010232the Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515010364
6 · The paper itself

Abstract

Treatment of highly aggressive triple-negative breast cancer (TNBC) in the clinic is challenging. Here, a liposome nanodrug (LP@PFH@HMME) integrating imaging agents and therapeutic agents for bimodal imaging-guided sonodynamic therapy (SDT) is developed, which boosted immunogenicity to enable potent immunotherapy via immune checkpoint blockade (ICB) in TNBC. In the acidic tumor microenvironment (TME), LP@PFH@HMME undergoes "nano-to-micro" transformation due to a pH-responsive lipid fusion, which makes droplets much more sensitive to ultrasound (US) in contrast-enhanced ultrasound (CEUS) and SDT studies. The nanodrug demonstrates robust bimodal imaging ability through fluorine-19 magnetic resonance imaging (

Indexed as

Immune Checkpoint InhibitorsTriple Negative Breast NeoplasmsUltrasonic TherapyAnimalsCell Line, TumorContrast MediaDisease Models, AnimalFemaleFluorine-19 Magnetic Resonance ImagingHumansImmunotherapyLiposomesMagnetic Resonance ImagingMiceTumor MicroenvironmentUltrasonographyContrast MediaImmune Checkpoint InhibitorsLiposomes19F magnetic resonance imagingbimodal imagingcontrast‐enhanced ultrasoundsonodynamic therapytriple‐negative breast cancer

Identifiers

PMID39051482
PMCPMC11423248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.