Evidence map›Paper›PMID 39051101›Full record

ArticleAnnals of medicine2024

Relationship between fraction of exhaled nitric oxide and peripheral eosinophilia in asthma.

Jane S Afriyie-Mensah, Philemon Domoyeri, Charles Antwi-Boasiako, Robert Aryee, Gifty B Dankwah, Mabel Ntiamoah, Bartholomew Dzudzor, Yaw Kusi-Mensah, Charles F Hayfron-Benjamin

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Article in Annals of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Longitudinal FeNO monitoring in pediatric asthma: association of FeNO and its trajectory patterns with asthma control status.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  3. Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jane S Afriyie-MensahDepartment of Medicine and Therapeutics, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Philemon DomoyeriDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Charles Antwi-BoasiakoDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Robert AryeeDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.ORCID 0000-0003-3643-4217
Gifty B DankwahDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Mabel NtiamoahCollege of Nursing, University of Cincinnati, Cincinnati, USA.
Bartholomew DzudzorDepartment of Medical Biochemistry, University of Ghana Medical School, Accra, Ghana.
Yaw Kusi-MensahDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Charles F Hayfron-BenjaminDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAchieving disease control is the goal of asthma management. Serum or sputum eosinophil counts have been known traditional means of assessing eosinophilic airway inflammation in asthma, which is vital in predicting response to corticosteroid therapy which ultimately promotes control of the disease. Evidence suggests that fraction of exhaled nitric oxide (FeNO) may be a more useful non-invasive surrogate biomarker for the assessment of eosinophilic airway inflammation and could help with the timely adjustment of inhaled corticosteroid therapy in the uncontrolled asthma patient. The relationship between FeNO and other markers of airway inflammation has been variable in literature, with limited data in sub-Saharan Africa where FeNO testing is very sparse. We sought to define the relationship between FeNO levels, serum eosinophil counts, spirometry measures and symptom control among asthma patients. MATERIALS AND

methodsThe study was conducted at the Asthma Clinic of a large tertiary hospital. This study included 82 patients with physician-diagnosed asthma being regularly managed at the clinic. All participants were taken through the asthma control test (ACT), had FeNO and spirometry measurements taken according to the American Thoracic Society (ATS) guidelines. Blood samples were obtained from all participants for serum eosinophil counts. Correlation coefficient was used to ascertain the relationship between FeNO levels and serum eosinophil counts, ACT scores, and spirometry measurements. Logistic regression was used to examine the association between high FeNO and abnormal FEV

resultsA total of 82 patients with asthma were included in the study, with higher prevalence of females (72%). Majority (40.2%) of the patients were found in the 60 and above age category. The median FeNO level and ACT score was 42.00 (26.00-52.50) parts per billion (ppb) and 20.0 (18-23) respectively. The median serum eosinophil counts was 0.25(0.90-0.38) × 10

conclusionFeNO levels significantly correlated with the ACT scores, serum eosinophil counts and FEV1% predicted among the asthma patients who were on inhaled corticosteroid therapy. High FeNO was significantly associated with abnormal FEV

Indexed as

AsthmaBiomarkersEosinophiliaEosinophilsNitric OxideSpirometryAdultBreath TestsExhalationFemaleFractional Exhaled Nitric Oxide TestingHumansLeukocyte CountMaleMiddle AgedBiomarkersNitric OxideAsthmaasthma control testeosinophil countsfraction of exhaled nitric oxidelung function

Identifiers

PMID39051101
PMCPMC11275527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.