Evidence map›Paper›PMID 39051081›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Effect of deletion of protein 4.1R on proliferation, apoptosis and glycolysis of hepatocyte HL-7702 cells].

M Zheng, Y Liu, J Liu, Q Kang, T Wang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M ZhengSchool of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
Y LiuSchool of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
J LiuSchool of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
Q KangSchool of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.
T WangSchool of Life Sciences, Zhengzhou University, Zhengzhou 450000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the effects of deletion of protein 4.1R on hepatocyte proliferation, apoptosis, and glycolysis and the molecular mechanisms.

methodsA 4.1R

resultsWestern blotting and sequencing analysis both confirmed the successful construction of 4.1R

conclusionDeletion of protein 4.1R in HL-7702 cells results in reduced proliferative capacity, increased apoptosis and suppression of glycolysis, and this regulatory mechanism is closely related with the activation of the downstream AMPK-mTORC1 signaling pathway.

Indexed as

ApoptosisCell ProliferationGlycolysisHepatocytesAMP-Activated Protein KinasesCell LineCRISPR-Cas SystemsGlucoseHumansSignal TransductionAMP-Activated Protein KinasesGlucoseglycolysishepatocytesproliferation and apoptosisprotein 4.1R

Identifiers

PMID39051081
PMCPMC11270666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.