Evidence map›Paper›PMID 39051079›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Therapeutic mechanism of aqueous extract of

Y Huang, L Qin, S Guan, Y Guang, Y Wei, A Cao, D Li, G Wei, Q Su

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Total flavonoids ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Y HuangCollege of Health Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
L QinCollege of Health Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
S GuanSchool of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou 510060, China.
Y GuangSchool of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou 510060, China.
Y WeiSchool of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou 510060, China.
A CaoSchool of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou 510060, China.
D LiGuangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning 530022, China.
G WeiGuangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning 530022, China.
Q SuCollege of Health Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the key targets and signaling pathways in the therapeutic mechanism of

methodsThe targets of SC and pancreatic cancer were predicted using the network pharmacological database, the protein-protein interaction network was constructed, and pathways, functional enrichment and molecular docking analyses were performed. CCK-8 assay was used to test the inhibitory effect of the aqueous extract of SC root on 8 cancer cell lines, and its effects on invasion, migration, proliferation, and apoptosis of pancreatic cancer cells were evaluated. Western blotting was performed to verify the results of network pharmacology analysis.

resultsWe identified a total of 18 active components in SC, which regulated 21 potential key targets in pancreatic cancer. GO and KEGG pathway enrichment analyses showed that these targets were involved mainly in the biological processes including protein phosphorylation, signal transduction, and apoptosis and participated in cancer signaling and PI3K-Akt signaling pathways. Among the 8 cancer cell lines, The aqueous extract of SC root produced the most obvious inhibitory effect in pancreatic cancer cells, and significantly inhibited the invasion, migration, and proliferation and promoted apoptosis of pancreatic cancer Panc-1 cells (

conclusionThe therapeutic effect of SC root against pancreatic cancer effects is mediated by its multiple components that act on different targets and pathways including the PI3K-Akt pathway.

Indexed as

ApoptosisCell MovementCell ProliferationMolecular Docking SimulationPancreatic NeoplasmsPlant RootsSignal TransductionCell Line, TumorDrugs, Chinese HerbalHumansNetwork PharmacologyPhosphatidylinositol 3-KinasesPlant ExtractsProtein Interaction MapsProto-Oncogene Proteins c-aktDrugs, Chinese HerbalPhosphatidylinositol 3-KinasesPlant ExtractsProto-Oncogene Proteins c-aktmolecular dockingnetwork pharmacologypancreatic cancerpathway analysisSemiliquidambar cathayensis Chang

Identifiers

PMID39051079
PMCPMC11270660

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.