ArticleGates open research2022
Nasopharyngeal Dysbiosis Precedes the Development of Lower Respiratory Tract Infections in Young Infants, a Longitudinal Infant Cohort Study.
Article in Gates open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Genomic and statistical models to characterizeMicrobial genomics · 2026Article
- Longitudinal Analysis of Nasopharyngeal Microbial Risk Markers for Fatal Acute Febrile Illness in a Zambian Birth Cohort.The Journal of infectious diseases · 2025Article
- The neonate respiratory microbiome.Acta physiologica (Oxford, England) · 2025Review
- Oropharyngeal detection of specific gut-derived Enterobacterales is associated with increased respiratory infection risk in older adults.Frontiers in aging · 2025Article
- Application of mindfulness-based stress reduction plan in post-stroke patients with mild depression.Frontiers in neurology · 2025Article
- Uncover a microbiota signature of upper respiratory tract in patients with SARS-CoV-2 + .Scientific reports · 2023Article
- Analysis of nasopharyngeal microbiome patterns in Zambian infants with fatal acute febrile illness.bioRxiv : the preprint server for biology · 2023Article
- Metagenomic profiling pipelines improve taxonomic classification for 16S amplicon sequencing data.Scientific reports · 2023Article
- Characterization of longitudinal nasopharyngeal microbiome patterns in maternally HIV-exposed Zambian infants.Gates open research · 2022Article
- Nasopharyngeal Dysbiosis Precedes the Development of Lower Respiratory Tract Infections in Young Infants, a Longitudinal Infant Cohort Study.Gates open research · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Background: Infants suffering from lower respiratory tract infections (LRTIs) have distinct nasopharyngeal (NP) microbiome profiles that correlate with severity of disease. Whether these profiles precede the infection or are a consequence of it, is unknown. In order to answer this question, longitudinal studies are needed. Methods: We conducted a retrospective analysis of NP samples collected in a longitudinal birth cohort study of Zambian mother-infant pairs. Samples were collected every two weeks from 1-week through 14-weeks of age. Ten of the infants in the cohort who developed LRTI were matched 1:3 with healthy comparators. We completed 16S rRNA gene sequencing on the samples each of these infants contributed and compared the NP microbiome of the healthy infants to infants who developed LRTI. Results: The infant NP microbiome maturation was characterized by transitioning from Conclusions: Our results suggest that specific characteristics of the NP microbiome precede LRTI in young infants and may be present in their mothers as well. Early dysbiosis may play a role in the causal pathway leading to LRTI or could be a marker of underlying immunological, environmental, or genetic characteristics that predispose to LRTI.
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