Evidence map›Paper›PMID 39050850›Full record

ArticleFrontiers in immunology2024

HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis.

Vicente Peris Sempere, Guo Luo, Sergio Muñiz-Castrillo, Anne-Laurie Pinto, Géraldine Picard, Véronique Rogemond, Maarten J Titulaer, Carsten Finke, Frank Leypoldt, Gregor Kuhlenbäumer and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  8. Autoimmune encephalitis-associated epilepsy.Nature reviews. Neurology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Vicente Peris Sempere *Stanford Center for Sleep Science and Medicine, Stanford University, Palo Alto, CA, United States.
Guo Luo *Stanford Center for Sleep Science and Medicine, Stanford University, Palo Alto, CA, United States.
Sergio Muñiz-CastrilloStanford Center for Sleep Science and Medicine, Stanford University, Palo Alto, CA, United States.
Anne-Laurie PintoFrench Reference Center on Paraneoplastic Neurological Syndrome and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France.
Géraldine PicardFrench Reference Center on Paraneoplastic Neurological Syndrome and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France.
Véronique RogemondFrench Reference Center on Paraneoplastic Neurological Syndrome and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France.
Maarten J TitulaerDepartment of Neurology, Erasmus Medical Center, Rotterdam, Netherlands.
Carsten FinkeDepartment of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Frank LeypoldtDepartment of Neurology, Christian-Albrechts-University/University Hospital Schleswig-Holstein, Kiel, Germany.
Gregor KuhlenbäumerDepartment of Neurology, Christian-Albrechts-University/University Hospital Schleswig-Holstein, Kiel, Germany.
GENERATE study group
Hannah F JonesStarship Hospital, Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Russell C DaleKids Neuroscience Centre, Children's Hospital at Westmead clinical school, University of Sydney, Sydney, NSW, Australia.
Sophie BinksOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Sarosh R IraniOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Anna E BastiaansenDepartment of Neurology, Erasmus Medical Center, Rotterdam, Netherlands.
Juna M de VriesDepartment of Neurology, Erasmus Medical Center, Rotterdam, Netherlands.
Marienke A A M de BruijnDepartment of Neurology, Erasmus Medical Center, Rotterdam, Netherlands.
Dave L RoelenDepartment of Immunogenetics and Transplantation Immunology, Leiden University Medical Center, Leiden, Netherlands.
Tae-Joon KimDepartment of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
Kon ChuDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Soon-Tae LeeDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Takamichi KanbayashiDepartment of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Nicholas R PollockDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, United States.
Katherine M KichulaDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, United States.
Abigail Mumme-MonheitDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, United States.
Jérôme Honnorat *French Reference Center on Paraneoplastic Neurological Syndrome and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France.
Paul J Norman *Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, United States.
Emmanuel Mignot *Stanford Center for Sleep Science and Medicine, Stanford University, Palo Alto, CA, United States.

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
NIAID NIH HHS U01 AI090905
6 · The paper itself

Abstract

Introduction: Genetic predisposition to autoimmune encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of associated environmental factors (tumors, infections), we hypothesized that human leukocyte antigen ( Methods: We conducted a Genome Wide Association Study (GWAS) with subsequent control-matching using Principal Component Analysis (PCA) and Results: Anti-NMDAR encephalitis showed a weak Discussion: Our observations for the first time suggest that the HLA-KIR axis might be involved in anti-NMDAR encephalitis. While the genetic risk conferred by the identified polymorphisms appears small, a role of this axis in the pathophysiology of this disease appears highly plausible and should be analyzed in future studies.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA AntigensKiller Cells, NaturalReceptors, KIRAdultFemaleHumansMaleMiddle AgedYoung AdultHLA AntigensReceptors, KIRanti-NMDAR encephalitisDQA1DQB1DRB1HLAKIRKIR2DL4KIR3DL3

Identifiers

PMID39050850
PMCPMC11266021

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.