Evidence map›Paper›PMID 39050847›Full record

ArticleFrontiers in immunology2024

Establishment and characterization of an h

Hongwei Liu, Terza Brostoff, Ana Ramirez, Talia Wong, Douglas J Rowland, Mollie Heffner, Arturo Flores, Brandon Willis, Jeffrey J Evans, Louise Lanoue and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Generation and characterization of a humanizedFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongwei LiuDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, United States.
Terza BrostoffDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, United States.
Ana RamirezDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, United States.
Talia WongDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, United States.
Douglas J RowlandCenter for Molecular and Genomic Imaging, College of Engineering, University of California, Davis, Davis, CA, United States.
Mollie HeffnerMouse Biology Program, University of California, Davis, Davis, CA, United States.
Arturo FloresDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, United States.
Brandon WillisMouse Biology Program, University of California, Davis, Davis, CA, United States.
Jeffrey J EvansMouse Biology Program, University of California, Davis, Davis, CA, United States.
Louise LanoueMouse Biology Program, University of California, Davis, Davis, CA, United States.
K C Kent LloydMouse Biology Program, University of California, Davis, Davis, CA, United States.
Lark L CoffeyDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, United States.

Funding

UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2M
Comparative Medical Science Training ProgramT32OD011147 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JEROEN SAEIJ, Sara Michelle Thomasy · 2012 to 2026
$5.5M
NIH HHS T32 OD011147NIH HHS U42 OD012210
6 · The paper itself

Abstract

Despite a substantial body of research, we lack fundamental understanding of the pathophysiology of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including pulmonary and cardiovascular outcomes, in part due to limitations of murine models. Most models use transgenic mice (K18) that express the human (h) angiotensin converting enzyme 2 (

Indexed as

Angiotensin-Converting Enzyme 2COVID-19Disease Models, AnimalGene Knock-In TechniquesMice, TransgenicSARS-CoV-2Serine EndopeptidasesAnimalsFemaleHumansLungMaleMiceMice, Inbred C57BLACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2Serine EndopeptidasesTMPRSS2 protein, mouseCOVID-19knock-in mousemouse ACE2mouse TMPRSS2pathogenesispulmonary functionSARS-CoV-2virus

Identifiers

PMID39050847
PMCPMC11266032

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.