Evidence map›Paper›PMID 39050824›Full record

ArticleFrontiers in molecular neuroscience2024

Context-dependent hyperactivity in

Sureni H Sumathipala, Suha Khan, Robert A Kozol, Yoichi Araki, Sheyum Syed, Richard L Huganir, Julia E Dallman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. TALE and Hox Transcription Factors Control Adult Behaviors in Zebrafish.bioRxiv : the preprint server for biology · 2026
    Article
  3. Convergence of autism proteins at the cilium.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Research progress inFrontiers in neurology
    Review
  6. Roadmap to advance therapeutics forTherapeutic advances in rare disease
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sureni H SumathipalaDepartment of Biology, University of Miami, Coral Gables, FL, United States.
Suha KhanDepartment of Biology, University of Miami, Coral Gables, FL, United States.
Robert A KozolDepartment of Biology, University of Miami, Coral Gables, FL, United States.
Yoichi ArakiDepartment of Neuroscience and Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Sheyum SyedDepartment of Physics, University of Miami, Coral Gables, FL, United States.
Richard L HuganirDepartment of Neuroscience and Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Julia E DallmanDepartment of Biology, University of Miami, Coral Gables, FL, United States.

Funding

The Dynamic AMPA Receptor Interactome During Plasticity and LearningR37NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Richard L Huganir · 2022 to 2026
$3.2M
Characterization of SynGAP Mutations in Human Cognitive DisordersR01MH112151 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 2017 to 2021
$2.7M
Gastrointestinal Comorbidities in Autism Spectrum DisordersR21HD093021 · NICHD · UNIVERSITY OF MIAMI CORAL GABLES · PI DALLMAN, JULIA EVE · 2018 to 2019
$403k
Stable Zebrafish Models of Autism Spectrum DisorderR03MH103857 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI DALLMAN, JULIA EVE · 2014 to 2015
$151k
NICHD NIH HHS R21 HD093021NIMH NIH HHS R01 MH112151NIMH NIH HHS R03 MH103857NINDS NIH HHS R37 NS036715
6 · The paper itself

Abstract

Background and aims: SYNGAP1-related disorder (SYNGAP1-RD) is a prevalent genetic form of Autism Spectrum Disorder and Intellectual Disability (ASD/ID) and is caused by Methods: We used CRISPR/Cas9 to introduce frameshift mutations in the Results: We show that CRISPR/Cas9 indels in zebrafish Limitations: Conclusion: Our data support mutations in zebrafish

Indexed as

autismhaploinsufficiency mutant profilingsensory-processingsyngap1zebrafish

Identifiers

PMID39050824
PMCPMC11266194

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.