ArticleResearch (Washington, D.C.)2024
Liquid Biopsy Instrument for Ultra-Fast and Label-Free Detection of Circulating Tumor Cells.
Article in Research (Washington, D.C.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Suppressing Blood-Cell Migration Lag via Dean-Cycle Phase Regulation Enables High-Purity CTC Enrichment in an Inertial Microfluidic Array.Micromachines · 2026Article
- Article
- Entropy-driven signal amplification integrated with machine learning in multiplex lateral flow immunoassay for sensitive Point-of-Care colon cancer diagnosis.Journal of nanobiotechnology · 2025Article
- A Mechanical Structure Design and Simulation-Based Validation of a Novel Compact and Low-Cost 3-DOF Robotic Arm.Sensors (Basel, Switzerland) · 2025Article
- Comprehensive Analysis of Shear Deformation Cytometry Based on Numerical Simulation Method.Biosensors · 2025Article
- Recent Advances in Microfluidic Impedance Detection: Principle, Design and Applications.Micromachines · 2025Review
- Clinical significance and heterogeneity of circulating tumor cells and clusters in breast cancer subtypes.PeerJ · 2025Review
- A Domain-Specific Pretrained Model for Detecting Malignant and Premalignant Ocular Surface Tumors: A Multicenter Model Development and Evaluation Study.Research (Washington, D.C.) · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid diagnosis and real-time monitoring are of great important in the fight against cancer. However, most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive. Here, we describe CytoExam, an automatic liquid biopsy instrument designed based on inertial microfluidics and impedance cytometry, which uses a deep learning algorithm for the analysis of circulating tumor cells (CTCs). In silico and in vitro experiments demonstrated that CytoExam could achieve label-free detection of CTCs in the peripheral blood of cancer patients within 15 min. The clinical applicability of CytoExam was also verified using peripheral blood samples from 10 healthy donors and >50 patients with breast, colorectal, or lung cancer. Significant differences in the number of collected cells and predicted CTCs were observed between the 2 groups, with variations in the dielectric properties of the collected cells from cancer patients also being observed. The ultra-fast and minimally invasive features of CytoExam may pave the way for new paths for cancer diagnosis and scientific research.
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Registered trials
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