Evidence map›Paper›PMID 39050781›Full record

ArticleBiological psychiatry global open science2024

Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome.

Emily M Hicks, Maria Niarchou, Slavina Goleva, Dia Kabir, Jessica Johnson, Keira J A Johnston, Julia Ciarcia, Gita A Pathak, Jordan W Smoller, Lea K Davis and 5 more

Abstract read
In one paragraph

Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Optimizing Symptom Surveys with Machine Learning to Predict PTSD One Year Post-trauma....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Emily M HicksPamela Sklar Division of Psychiatric Genetics, Icahn School of Medicine at Mount Sinai, New York, New York.
Maria NiarchouVanderbilt University Medical Center, Vanderbilt Genetics Institute, Nashville, Tennessee.
Slavina GolevaVanderbilt University Medical Center, Vanderbilt Genetics Institute, Nashville, Tennessee.
Dia KabirDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Jessica JohnsonPamela Sklar Division of Psychiatric Genetics, Icahn School of Medicine at Mount Sinai, New York, New York.
Keira J A JohnstonDepartment of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Julia CiarciaDepartment of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Gita A PathakDepartment of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Jordan W SmollerDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Lea K DavisVanderbilt University Medical Center, Vanderbilt Genetics Institute, Nashville, Tennessee.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, La Jolla, California.
Karestan C KoenenBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, Massachusetts.
Laura M HuckinsDepartment of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Karmel W ChoiDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
PGC/PsycheMERGE PTSD & Trauma EHR Working Group

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Integrating Health Records, Genomic, and Social Data to Stratify Adolescent Depression RiskK08MH127413 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, KARMEL · 2021 to 2025
$987k
NICHD NIH HHS P50 HD103537NIMH NIH HHS K08 MH127413
6 · The paper itself

Abstract

Background: Previous epidemiological research has linked posttraumatic stress disorder (PTSD) with specific physical health problems, but the comprehensive landscape of medical conditions associated with PTSD remains uncharacterized. Electronic health records provide an opportunity to overcome clinical knowledge gaps and uncover associations with biological relevance that potentially vary by sex. Methods: PTSD was defined among biobank participants ( Results: A substantial number of phecodes were significantly associated with PTSD Conclusions: This study provides valuable insights into a diverse range of comorbidities associated with PTSD, including both known and novel associations, while highlighting the influence of sex differences and the impact of defining PTSD using electronic health records.

Indexed as

ComorbiditiesElectronic health recordPhenome-wide association studyPTSDSex specificityTrauma

Identifiers

PMID39050781
PMCPMC11268109

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.