ArticleFrontiers in neuroscience2024
Investigating spatiotemporal and kinematic gait parameters in individuals with Parkinson's disease with a history of freezing of gait and exploring the effects of dopaminergic therapy on freezing of gait subtypes.
Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The rising tide of frailty in Parkinson's disease: a bibliometric study of global research landscape and emerging trends.Frontiers in neurologyPooled it
- Passive sensing of gait and medication-related fluctuations in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Is levodopa induced freezing of gait a paradox or an expected phenomenon?: a clinico-pathophysiological hypothesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Uncovering the Kinematic Signature of Freezing of Gait in Parkinson's Disease Through Wearable Inertial Sensors.Sensors (Basel, Switzerland) · 2025Article
- Predicting Freezing of Gait in Parkinson's Disease: A Machine-Learning-Based Approach in ON and OFF Medication States.Journal of clinical medicine · 2025Article
- Early detection of Parkinson's disease using a multi area graph convolutional network.Scientific reports · 2025Article
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Authors and funding
8 authors.
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Abstract
Introduction: Freezing of Gait (FOG) is a prevalent and debilitating symptom in idiopathic Parkinson's disease (PD). This study evaluated spatiotemporal and kinematic gait parameters in individuals with PD with a history of FOG and explored the effects of dopaminergic therapy on FOG subtypes. Methods: One hundred and nine individuals with PD underwent clinical assessments and quantitative biomechanical measures during walking cycles before and after dopaminergic therapy. Individuals with FOG were classified into levodopa-responsive and levodopa-unresponsive groups. Results: Individuals with FOG displayed longer disease duration and higher Unified Parkinson's Disease Rating Scale (UPDRS) II, III, IV scores, and total scores and levodopa equivalent dose, than those without FOG (all Discussion: Dopaminergic therapy had varying effects on PD with FOG, improving several spatiotemporal and kinematic gait parameters but being less effective in levodopa-unresponsive cases. Quantitative biomechanical measures offer detailed insights into gait performance, aiding personalized fall risk assessment and guiding individualized rehabilitation programs.
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