ArticleJournal of experimental orthopaedics2024
Satellite myoblast and mesenchymal stem cell injections decrease fatty degeneration after rotator cuff tear in rats.
Article in Journal of experimental orthopaedics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Comparative effects of bone marrow stimulation and shockwave therapy on rotator cuff healing in chronic massive rotator cuff tears: A rat model study.Journal of experimental orthopaedics · 2026Article
- Satellite myoblast and mesenchymal stem cell injections decrease fatty degeneration after rotator cuff tear in rats.Journal of experimental orthopaedics · 2024Article
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7 authors.
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Abstract
Purpose: Rotator cuff (RC) tears cause fatty degeneration, aggravated by delayed treatment. Surgical repair alone cannot reverse fatty degeneration. It was aimed to test if local injections of satellite cell-derived myoblasts or satellite myoblasts (SM) from the deltoid region and mesenchymal stem cells (MSCs) from the subcutaneous abdominal fat pad would stimulate myogenesis and decrease adipogenesis in the rat model of fatty degenerated RC tear. Methods: A standardized RC tear surgery was performed on both shoulders of 24 Wistar albino rats at Results: Histological and histomorphometric analyses were performed in week 14. The repair + SM and MSC group had a significantly greater supraspinatus muscle mass than the repair only and control groups. The adipose tissue ratio was significantly lower in the repair + SM and MSC groups versus the repair only and control groups. Conclusion: Histologically, the repair + SM and MSC group had improved muscle and tendon organization. In treating chronically degenerated RC tear in a rat model, surgical repair combined with injections of SM and MSC improved fatty degeneration, tendon healing and myogenesis. Level of Evidence: Level III.
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