Evidence map›Paper›PMID 39050368›Full record

ArticleFrontiers in toxicology2024

Bioactivation of cinnamic alcohol in a reconstructed human epidermis model and evaluation of sensitizing potency of the identified metabolites.

Lorena Ndreu, Josefine Carlsson, David J Ponting, Ida B Niklasson, E Johanna L Stéen, Lukas McHugh, Niamh M O'Boyle, Kristina Luthman, Ann-Therese Karlberg, Isabella Karlsson

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Article in Frontiers in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nanoencapsulation ofRSC advances · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lorena NdreuDepartment of Environmental Science, Exposure, and Effect, Stockholm University, Stockholm, Sweden.
Josefine CarlssonDepartment of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden.
David J PontingDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden.
Ida B NiklassonDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden.
E Johanna L StéenDepartment of Chemistry and Molecular Biology, Medicinal Chemistry, University of Gothenburg, Gothenburg, Sweden.
Lukas McHughDepartment of Environmental Science, Exposure, and Effect, Stockholm University, Stockholm, Sweden.
Niamh M O'BoyleSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Panoz Institute and Trinity Biomedical Sciences Institute, Dublin, Ireland.
Kristina LuthmanDepartment of Chemistry and Molecular Biology, Medicinal Chemistry, University of Gothenburg, Gothenburg, Sweden.
Ann-Therese KarlbergDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden.
Isabella KarlssonDepartment of Environmental Science, Exposure, and Effect, Stockholm University, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cinnamic alcohol is a natural compound, widely used in fragrances, which can cause allergic contact dermatitis. Cinnamic alcohol lacks intrinsic reactivity and autoxidation or metabolic activation is necessary for it to act as a sensitizer. Methods: Bioactivation of cinnamic alcohol was explored using human liver microsomes, human liver S9 and SkinEthic™ Reconstructed Human Epidermis. A targeted multiple reaction monitoring mass spectrometry method was employed to study and quantify cinnamic alcohol along with eight potential phase I or phase II metabolites. The reconstructed human epidermis model, treated with cinnamic alcohol, was also analyzed with a non-targeted high-resolution mass spectrometry method to identify metabolites not included in the targeted method. Results: Two metabolites identified with the targeted method, namely, pOH-cinnamic alcohol and pOH-cinnamic aldehyde, have not previously been identified in a metabolic Discussion: Cinnamic alcohol is one of the most common fragrance allergens and as it is more effective to patch test with the actual sensitizer than with the prohapten itself, it is important to identify metabolites with sensitizing potency. Further, improved knowledge of metabolic transformations occurring in the skin can improve prediction models for safety assessment of skin products.

Indexed as

biotransformationcinnamic alcoholcinnamic sulfatelocal lymph node assay (LLNA)mass spectrometrypOH-cinnamic alcoholpOH-cinnamic aldehydereconstructed human epidermis

Identifiers

PMID39050368
PMCPMC11266153

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.