ArticleWorld journal of emergency medicine2024
Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department.
Article in World journal of emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- From early recognition to precision medicine: advances in the diagnosis and management of adult sepsis and septic shock-a narrative review.Infection · 2026Review
- Impact of early albumin therapy on 28-day survival in ICU patients with septic shock concurrent hypoalbuminemia: a retrospective analysis of combined clinical datasets.World journal of emergency medicine · 2026Article
- Discrimination performance of the Phoenix sepsis score versus pediatric sequential organ failure assessment for predicting in-hospital mortality in critically ill children: a multicenter external validation study.World journal of pediatrics : WJP · 2026Article
- The evolution of sepsis care: from protocol-driven management to personalized intensive care.Infection · 2026Review
- The Brazilian risk assessment severity index score: a novel tool for predicting in-hospital mortality in emergency departments.World journal of emergency medicine · 2026Article
- Prediction of infection in the emergency department-a machine learning model.Frontiers in artificial intelligence · 2026Article
- Shock index-modified qSOFA improves mortality risk stratification in patients with sepsis beyond conventional qSOFA.Frontiers in medicine · 2026Article
- Performance of a novel medical artificial intelligence large language model on supporting decision-making for emergency patients with suspected sepsis.World journal of emergency medicine · 2025Article
- Long-term cardiovascular outcomes and risk factors in adult sepsis survivors: a systematic review and meta-analysis.World journal of emergency medicine · 2025Review
- Prehospital critical care drug-therapy and 30-day mortality in patients with acute respiratory disease.World journal of emergency medicine · 2025Article
- Early identification of high-risk patients admitted to emergency departments using vital signs and machine learning.World journal of emergency medicine · 2025Article
- Application of myxovirus resistance protein A in the etiological diagnosis of infections in adults.World journal of emergency medicine · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundThis study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores (EWSs) and three shock indices in early sepsis prediction in the emergency department (ED).
methodsWe performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong Kong. The primary outcome was sepsis (Sepsis-3 definition) within 48 h of ED presentation. Using c-statistics and the DeLong test, we compared 11 EWSs, including the National Early Warning Score 2 (NEWS2), Modified Early Warning Score, and Worthing Physiological Scoring System (WPS), etc., and three shock indices (the shock index [SI], modified shock index [MSI], and diastolic shock index [DSI]), with Systemic Inflammatory Response Syndrome (SIRS) and quick Sequential Organ Failure Assessment (qSOFA) in predicting the primary outcome, intensive care unit admission, and mortality at different time points.
resultsWe analyzed 601 patients, of whom 166 (27.6%) developed sepsis. NEWS2 had the highest point estimate (area under the receiver operating characteristic curve [AUROC] 0.75, 95%
conclusionNEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.
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