Evidence map›Paper›PMID 39049847›Full record

ArticleJournal of ophthalmology2024

ABCA1 Deletion Does Not Affect Aqueous Humor Outflow Function in Mice.

Bo Qin, Chunchun Hu, Youjia Zhang, Yuhong Chen, Yuan Lei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bo QinDepartment of Ophthalmology and Visual Science Eye and ENT Hospital Shanghai Medical College Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-1230-9932
Chunchun HuDepartment of Ophthalmology and Visual Science Eye and ENT Hospital Shanghai Medical College Fudan University, Shanghai, China.
Youjia ZhangDepartment of Ophthalmology and Visual Science Eye and ENT Hospital Shanghai Medical College Fudan University, Shanghai, China.
Yuhong ChenDepartment of Ophthalmology and Visual Science Eye and ENT Hospital Shanghai Medical College Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-6131-7595
Yuan LeiDepartment of Ophthalmology and Visual Science Eye and ENT Hospital Shanghai Medical College Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-5651-0948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: ATP binding cassette transporter A1 (ABCA1) is a candidate gene within a POAG susceptibility locus by GWAS analysis, and it is involved in IOP modulation via the Cav1/eNOS/NO signaling pathway. We aim to examine the phenotype of ABCA1 deletion in the ABCA1 gene knockout (Abca1 Methods: The anterior segments of Abca1 Results: There was no significant difference in the anterior segment morphology of Abca1 Conclusion: ABCA1 deletion does not affect IOP and aqueous humor outflow function but the Cav1/eNOS/NO pathway is changed in Abca1

Identifiers

PMID39049847
PMCPMC11268963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.