Evidence map›Paper›PMID 39049187›Full record

ArticleCancer medicine2024

Water-filtered infrared A radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours.

Pengyuan Liu, Jing Wu, Liting Chen, Zhenhai Wu, Yufei Wu, Ganlu Zhang, Bingqi Yu, Beibei Zhang, Nan Wei, Jinan Shi and 15 more

Registry-linked trialAbstract read
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07564440 (Clinical and Biological Safety Study of the BTT Hyperthermia in Adult Subjects), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07564440 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Clinical and Biological Safety Study of the BTT Hyperthermia in Adult Subjects

TypeinterventionalSponsorMarc AbreuRan2026 to 2026Enrolled20ConditionsSafety StudyArmsHyperthermia
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Pengyuan LiuDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.ORCID 0000-0003-1338-2266
Jing WuDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Liting ChenDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Zhenhai WuDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Yufei WuACS (International) School of Singapore, Singapore.
Ganlu ZhangDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Bingqi YuDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Beibei ZhangDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Nan WeiDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Jinan ShiDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Chuanfeng ZhangDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Lan LeiDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Shuhuan YuDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Jianjun LaiDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Zhen GuoDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Yuli ZhengDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Zhao JingDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.ORCID 0000-0002-6566-599X
Hao JiangDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Tingxiang WangDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.
Jueyi ZhouDepartment of Oncology, Lishui People's Hospital, Lishui, China.
Yajun WuTCM Dispensary, Zhejiang Hospital, Hangzhou, China.
Chuan SunGeriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
Jie ShenDepartment of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jian ZhangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhibing WuDepartment of Oncology, Zhejiang Hospital, Hangzhou, China.ORCID 0000-0003-2059-7142

Funding

Zhejiang Medical and Health Science and Technology Project 2021KY434Zhejiang Medical and Health Science and Technology Project 2024KY005Zhejiang Provincial Medical Association Clinical Medical Research Major Project Foundation 2022ZYC-D01
6 · The paper itself

Abstract

This study pioneered the use of WIRA whole-body infrared hyperthermia combined with ICI therapy to treat GIT and verified the feasibility and safety of HIT. The final results showed a DCR of 55.6%, with a median PFS of 53.5 days, median OS of 134 days, and an irAE incidence of 22.2%. Therefore, we believe that HIT can exert multiple synergistic sensitisation effects, thereby providing clinical benefits to patients with advanced GITs, increasing overall safety, and improving patients' QOL.

Indexed as

Gastrointestinal NeoplasmsHyperthermia, InducedImmunotherapyInfrared RaysAdultAgedCombined Modality TherapyFemaleHumansMaleMiddle AgedQuality of LifeTreatment OutcomeWaterWater

Identifiers

PMID39049187
PMCPMC11269209

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.