ArticleBMC medical genomics2024
Causal effect of the age at first birth with depression: a mendelian randomization study.
Article in BMC medical genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Article
- The association between the transition to parenthood and risk for nonfatal suicide attempt in a Swedish population-based sample.Psychological medicine · 2026Article
- Association Between Maternal Genome-Wide Polygenic Scores for Psychiatric and Neurodevelopmental Disorders and Adverse Perinatal Events: A Danish Population-Based Study.Biological psychiatry global open science · 2026Article
- Associations of Birth Interval With Prevalence of Depression in Postmenopausal Women.Depression and anxiety · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThis study aimed to explore the causal relationship between age at first birth (AFB) and depression.
methodsUsing the univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) methods to examine the potential correlation between age at first birth (AFB) and major depressive disorder and postpartum depression. A public database was used to obtain the genome-wide association studies (GWAS) summary data. We put inverse-variance-weighted (IVW) as the primary method in Mendelian randomization (MR) analysis and used sensitivity analysis to confirm the robustness of our result.
resultsWe found a significant causal association between AFB and major depressive disorder by using the IVW algorithm (odd ratio [OR] 0.826; 95% confidence interval [CI] 0.793 - 0.861; P = 4.51 × 10
conclusionThere is solid evidence that a higher age at first birth is associated with a lower risk of major depressive disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.